Nelson D A, Barondess D A, Hendrix S L, Beck T J
Department of Internal Medicine, Wayne State University, Hutzel Hospital, Detroit, Michigan 48201, USA.
J Bone Miner Res. 2000 Oct;15(10):1992-7. doi: 10.1359/jbmr.2000.15.10.1992.
Osteoporosis is characterized by both a low bone mass and a disruption of the architectural arrangement of bone tissue, leading to decreased skeletal strength and increased fracture risk. Although there are well-known ethnic differences in bone mass and fracture risk, little is known about possible ethnic differences in bone structure. Therefore, we studied cross-sectional geometry in the hip in a sample of postmenopausal black and white women in order to investigate ethnic differences that might contribute to differences in bone strength and ultimately hip fracture risk. We recruited 371 postmenopausal black and white women who were entering the Women's Health Initiative (WHI) clinical trials in Detroit. Bone density measurements of the proximal femur were done by dual-energy X-ray absorptiometry (DXA) using a Hologic 1000 Plus bone densitometer. The DXA data were used for hip structure analysis, which treats the entire proximal femur as a continuous curved beam from the proximal shaft to the femoral neck. This permits the analysis of cross-sectional geometric properties in two narrow regions corresponding to thin (5 mm) cross-sectional slabs seen on edge. The results indicate significant ethnic differences in bone density, cross-sectional geometry, and dimensional variables. Specifically, the black women have a significantly higher bone density in both locations (10.1% and 4.1% for the neck and shaft, respectively); greater cross-sectional geometric properties in the neck (ranging from 6.1% to 11.6%), but a smaller endocortical diameter in the neck (3.6%). There are fewer significant differences in cross-sectional geometry in the shaft location. Our data suggest that the spatial distribution of bone is arranged in the femoral neck to resist greater loading in black women compared with white women.
骨质疏松症的特征是骨量低和骨组织结构排列紊乱，导致骨骼强度下降和骨折风险增加。尽管骨量和骨折风险存在众所周知的种族差异，但对于骨结构可能存在的种族差异知之甚少。因此，我们对绝经后黑人和白人女性样本的髋部横截面几何形状进行了研究，以调查可能导致骨强度差异并最终导致髋部骨折风险差异的种族差异。我们招募了371名进入底特律妇女健康倡议（WHI）临床试验的绝经后黑人和白人女性。使用Hologic 1000 Plus骨密度仪通过双能X线吸收法（DXA）对近端股骨进行骨密度测量。DXA数据用于髋部结构分析，该分析将整个近端股骨视为从近端骨干到股骨颈的连续弯曲梁。这允许在与边缘看到的薄（5毫米）横截面平板相对应的两个狭窄区域分析横截面几何特性。结果表明，在骨密度、横截面几何形状和尺寸变量方面存在显著的种族差异。具体而言，黑人女性在两个部位的骨密度均显著更高（颈部和骨干分别为10.1%和4.1%）；颈部的横截面几何特性更大（范围为6.1%至11.6%），但颈部的内皮质直径更小（3.6%）。骨干部位的横截面几何形状差异较小。我们的数据表明，与白人女性相比，黑人女性股骨颈中的骨空间分布是为了抵抗更大的负荷。
