Shum Ho Cheung, Abate Adam R, Lee Daeyeon, Studart André R, Wang Baoguo, Chen Chia-Hung, Thiele Julian, Shah Rhutesh K, Krummel Amber, Weitz David A
School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
Macromol Rapid Commun. 2010 Jan 18;31(2):108-18. doi: 10.1002/marc.200900590. Epub 2009 Nov 24.
We describe new developments for controlled fabrication of monodisperse non-spherical particles using droplet microfluidics. The high degree of control afforded by microfluidic technologies enables generation of single and multiple emulsion droplets. We show that these droplets can be transformed to non-spherical particles through further simple, spontaneous processing steps, including arrested coalescence, asymmetric polymer solidification, polymerization in microfluidic flow, and evaporation-driven clustering. These versatile and scalable microfluidic approaches can be used for producing large quantities of non-spherical particles that are monodisperse in both size and shape; these have great potential for commercial applications.
我们描述了利用液滴微流控技术可控制备单分散非球形颗粒的新进展。微流控技术提供的高度控制能力能够生成单乳液滴和多乳液滴。我们表明，通过进一步简单的自发加工步骤，包括阻止聚结、不对称聚合物固化、微流控流动中的聚合以及蒸发驱动聚集，这些液滴可以转化为非球形颗粒。这些通用且可扩展的微流控方法可用于生产大量尺寸和形状均单分散的非球形颗粒；它们具有巨大的商业应用潜力。
