Roy Urmi, Luck Linda A
From the Center for Advanced Materials Processing, Clarkson University, Potsdam, New York 13699-5665.
Biochem Mol Biol Educ. 2007 Jul;35(4):238-43. doi: 10.1002/bmb.65. Epub 2007 Jul 3.
Molecular modeling is pervasive in the pharmaceutical industry that employs many of our students from Biology, Chemistry and the interdisciplinary majors. To expose our students to this important aspect of their education we have incorporated a set of tutorials in our Biochemistry class. The present article describes one of our tutorials where undergraduates use modeling experiments to explore the structure of an estrogen receptor. We have employed the Molecular Operating Environment, a powerful molecular visualization software, which can be implemented on a variety of operating platforms. This tutorial reinforces the concepts of ligand binding, hydrophobicity, hydrogen bonding, and the properties of side chains and secondary structure taught in a general biochemistry class utilizing a protein that has importance in human biology.
分子建模在制药行业中很普遍，我们生物、化学及跨学科专业的许多学生都受雇于该行业。为了让我们的学生接触到他们教育中的这一重要方面，我们在生物化学课程中纳入了一系列教程。本文描述了我们的一个教程，本科生通过建模实验来探索雌激素受体的结构。我们使用了分子操作环境（Molecular Operating Environment），这是一款强大的分子可视化软件，可在多种操作平台上运行。本教程利用一种在人类生物学中具有重要意义的蛋白质，强化了普通生物化学课程中讲授的配体结合、疏水性、氢键以及侧链和二级结构特性等概念。
