Institute of Tissue Regeneration Engineering (ITREN), Dankook University, South Korea; Department of Biomaterials Science, School of Dentistry, Dankook University, South Korea.
J Biomed Mater Res B Appl Biomater. 2011 Aug;98(2):246-54. doi: 10.1002/jbm.b.31846. Epub 2011 May 17.
Degradable polymer-based materials are attractive in orthopedics and dentistry as an alternative to metallic implants for use as bone fixatives. Herein, a degradable polymer poly(lactic acid) (PLA) was combined with novel hybrid nanopowder of carbon nanotubes (CNTs)-calcium phosphate (CP) for this application. In particular, CNTs-CP hybrid nanopowders (0.1 and 0.25% CNTs) were prepared from the solution of ionically modified CNTs (mCNTs), which was specifically synthesized to be well-dispersed and thus to effectively adsorb onto the CP nanoparticles. The mCNTs-CP hybrid nanopowders were then mixed with PLA (up to 50%) to produce mCNTs-CP-PLA nanocomposites. The mechanical tensile strength of the nanocomposites was significantly improved by the addition of mCNTs-CP hybrid nanopowders. Moreover, nanocomposites containing low concentration of mCNTs (0.1%) showed significantly stimulated biological responses including cell proliferation and osteoblastic differentiation in terms of gene and protein expressions. Based on this study, the addition of novel mCNT-CP hybrid nanopowders to PLA biopolymer may be considered a new material choice for developing hard tissue implants.
可降解聚合物基材料作为金属植入物的替代品，在骨科和牙科领域具有吸引力，可作为骨固定剂。在此，将可降解聚合物聚乳酸（PLA）与新型碳纳米管（CNT）-磷酸钙（CP）混合纳米粉末用于该应用。具体而言，通过离子改性 CNT（mCNTs）的溶液制备 CNT-CP 混合纳米粉末（0.1%和 0.25%的 CNT），专门合成 mCNTs 以实现良好分散，从而有效地吸附到 CP 纳米颗粒上。然后将 mCNTs-CP 混合纳米粉末与 PLA（高达 50%）混合，以制备 mCNTs-CP-PLA 纳米复合材料。通过添加 mCNTs-CP 混合纳米粉末，纳米复合材料的机械拉伸强度显著提高。此外，含有低浓度 mCNTs（0.1%）的纳米复合材料在基因和蛋白质表达方面表现出明显的刺激细胞增殖和成骨细胞分化的生物响应。基于这项研究，将新型 mCNT-CP 混合纳米粉末添加到 PLA 生物聚合物中，可能被认为是开发硬组织植入物的新材料选择。
