Beer A-M, Wegener T
Abteilung für Naturheilkunde und Gesundheitsprävention (Abteilung Allgemeinmedizin), Ruhr-Universität Bochum.
MMW Fortschr Med. 2011 Mar 31;153 Suppl 1:14-20.
Inflammatory processes release reactive oxygen species, destroying cartilage tissue. Vitamin E is an antioxidant and protects cartilage tissue. Dietary intake of vitamin E is often low in patients with osteoarthrosis, and short term clinical studies have shown symptomatic relief in pain. Therefore, efficacy and tolerability of vitamin E are investigated in routine use of medical practitioners.
Open, multicentric observational study including 151 patients with osteoarthritis (knee, hip): 85 patients were treated with 333,5 mg RRR-alpha-tocopherol (monotherapy), 61 patients with 333,5 mg RRR-alpha-tocopherol and a further analgesic (combination therapy). 5 patients (2 monotherapy, 3 combination) failed to turn up for follow-up (dropout). According to the study design, the physician was free in his treatment (assignment to treatment, choice of analgesic). After 4, 8, and 12 weeks the efficacy and tolerability were determined by physicians and by patients.
Demographic data were comparable in both groups, however clinical condition was slightly worse in the combination group. In the course of the treatment, all parameters improved in both groups. Monotherapy was somewhat less effective and set on later. There were two adverse events in the monotherapy group (total endoprosthesis, itching). Tolerability of monotherapy was rated slightly better than combination therapy by physicians and by patients.
For patients with gonarthrosis or coxarthrosis the supplementation of Vitamin E to an analgetic medication is reasonable and well tolerated.
炎症过程会释放活性氧，破坏软骨组织。维生素E是一种抗氧化剂，可保护软骨组织。骨关节炎患者的维生素E饮食摄入量通常较低，短期临床研究表明疼痛症状有所缓解。因此，研究了维生素E在医生常规使用中的疗效和耐受性。
开放性、多中心观察性研究，纳入151例骨关节炎（膝关节、髋关节）患者：85例患者接受333.5毫克RRR-α-生育酚治疗（单一疗法），61例患者接受333.5毫克RRR-α-生育酚与另一种镇痛药联合治疗（联合疗法）。5例患者（2例单一疗法，3例联合疗法）未前来随访（失访）。根据研究设计，医生在治疗方面（分配治疗、选择镇痛药）具有自主性。在4周、8周和12周后，由医生和患者确定疗效和耐受性。
两组的人口统计学数据具有可比性，但联合治疗组的临床状况略差。在治疗过程中，两组的所有参数均有所改善。单一疗法的效果稍差且起效较晚。单一疗法组出现两例不良事件（全关节置换、瘙痒）。医生和患者对单一疗法耐受性的评价略高于联合疗法。
对于膝关节炎或髋关节炎患者，在镇痛药中补充维生素E是合理的，且耐受性良好。
