Sugano Teppei, Mori Masahide, Namba Yoshinobu, Uenami Takeshi, Kagami Shin-ichi, Yokota Soichiro
Department of Thoracic Oncology, National Hospital Organization Toneyama National Hospital.
Nihon Kokyuki Gakkai Zasshi. 2011 Apr;49(4):304-8.
A 63-year-old male smoker with left chest pain was admitted for examination of an abnormal chest shadow. A chest computed tomography (CT) scan revealed a tumor in S6 of the left lung, and left pleural effusion. Histological examination by CT-guided needle biopsy revealed a proliferation of spindle-shaped tumor cells with sarcomatous features. Immunohistochemical staining confirmed the tumor cells to be of epidermal origin, indicating a diagnosis of sarcomatoid carcinoma of the lung. No distant metastases were found, and his disease was judged to be clinical stage IV (T3N2M1a). He received 5 courses of systemic chemotherapy consisting of carboplatin, paclitaxel and bevacizumab, and the tumor shrank. Systemic chemotherapy is generally ineffective for sarcomatoid carcinoma of the lung. However, in the present case this chemotherapy was effective with the addition of bevacizumab.
一名63岁有吸烟史的男性因左胸痛入院检查，胸部出现异常阴影。胸部计算机断层扫描（CT）显示左肺S6区有肿瘤及左侧胸腔积液。CT引导下针吸活检的组织学检查显示梭形肿瘤细胞增生，具有肉瘤特征。免疫组化染色证实肿瘤细胞起源于上皮，诊断为肺肉瘤样癌。未发现远处转移，其疾病判定为临床IV期（T3N2M1a）。他接受了5个疗程由卡铂、紫杉醇和贝伐单抗组成的全身化疗，肿瘤缩小。全身化疗对肺肉瘤样癌一般无效。然而，在本病例中，加用贝伐单抗后化疗有效。
