皮肤T细胞淋巴瘤的治疗进展
Therapeutic advances in cutaneous T-cell lymphoma.
作者信息
Akilov Oleg E, Geskin Larisa
机构信息
Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA.
出版信息
Skin Therapy Lett. 2011 Feb;16(2):1-5.
Abstract
A variety of novel therapeutic modalities have recently become available for patients with cutaneous T cell lymphoma (CTCL). In particular, with recent FDA approvals of the three new agents vorinostat (Zolinza), romidepsin (Istodax), and pralatrexate (Folotyn) CTCL treatment has been transformed. Here, we offer a brief overview of these agents and discuss their place in the spectrum of current therapies for CTCL.
摘要
最近，多种新型治疗方式已可供皮肤T细胞淋巴瘤（CTCL）患者使用。特别是，随着美国食品药品监督管理局（FDA）最近批准了三种新药：伏立诺他（Zolinza）、罗米地辛（Istodax）和普拉曲沙（Folotyn），CTCL的治疗发生了变革。在此，我们简要概述这些药物，并讨论它们在CTCL当前治疗方案中的地位。
相似文献
1
Therapeutic advances in cutaneous T-cell lymphoma.皮肤T细胞淋巴瘤的治疗进展
Skin Therapy Lett. 2011 Feb;16(2):1-5.
2
Current and emerging treatment strategies for cutaneous T-cell lymphoma.皮肤 T 细胞淋巴瘤的当前和新兴治疗策略。
Drugs. 2010 Feb 12;70(3):273-86. doi: 10.2165/11532190-000000000-00000.
3
Kinome profiling analysis identified Src pathway as a novel therapeutic target in combination with histone deacetylase inhibitors for cutaneous T-cell lymphoma.激酶组谱分析确定 Src 通路与组蛋白去乙酰化酶抑制剂联合治疗皮肤 T 细胞淋巴瘤是一种新的治疗靶点。
J Dermatol Sci. 2021 Mar;101(3):194-201. doi: 10.1016/j.jdermsci.2021.01.004. Epub 2021 Jan 22.
4
Cutaneous T cell lymphoma: update on treatment.皮肤 T 细胞淋巴瘤：治疗进展。
Int J Dermatol. 2012 Sep;51(9):1019-36. doi: 10.1111/j.1365-4632.2011.05337.x.
5
Cutaneous T cell Lymphoma: an Update on Pathogenesis and Systemic Therapy.皮肤T细胞淋巴瘤：发病机制与全身治疗的最新进展
Curr Hematol Malig Rep. 2015 Dec;10(4):468-76. doi: 10.1007/s11899-015-0293-y.
6
The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells.组蛋白去乙酰化酶抑制剂伏立诺他和罗米地辛下调皮肤 T 细胞淋巴瘤细胞中 IL-10 的表达。
Br J Pharmacol. 2011 Apr;162(7):1590-602. doi: 10.1111/j.1476-5381.2010.01188.x.
7
HDAC inhibitors for the treatment of cutaneous T-cell lymphomas.组蛋白去乙酰化酶抑制剂治疗皮肤 T 细胞淋巴瘤。
Future Med Chem. 2012 Mar;4(4):471-86. doi: 10.4155/fmc.12.6.
8
Synergy of BCL2 and histone deacetylase inhibition against leukemic cells from cutaneous T-cell lymphoma patients.BCL2与组蛋白脱乙酰酶抑制对皮肤T细胞淋巴瘤患者白血病细胞的协同作用。
Blood. 2017 Nov 9;130(19):2073-2083. doi: 10.1182/blood-2017-06-792150. Epub 2017 Oct 2.
9
Management of refractory early-stage cutaneous T-cell lymphoma.难治性早期皮肤T细胞淋巴瘤的管理
Am J Clin Dermatol. 2006;7(3):155-69. doi: 10.2165/00128071-200607030-00002.
10
[Therapeutic perspectives of cutaneous T-cell lymphoma].[皮肤T细胞淋巴瘤的治疗前景]
Ann Dermatol Venereol. 2011 May;138(5 Suppl 2):H19-22. doi: 10.1016/S0151-9638(11)70072-2.
引用本文的文献
1
Functional Depletion of HSP72 by siRNA and Quercetin Enhances Vorinostat-Induced Apoptosis in an HSP72-Overexpressing Cutaneous T-Cell Lymphoma Cell Line, Hut78.siRNA 和槲皮素对 HSP72 的功能耗竭增强 HSP72 过表达皮肤 T 细胞淋巴瘤细胞系 Hut78 中伏立诺他诱导的细胞凋亡
Int J Mol Sci. 2021 Oct 19;22(20):11258. doi: 10.3390/ijms222011258.
2
Therapeutic effects of topical 0.03% Tacrolimus ointment in children with refractory vernal keratoconjunctivitis in Middle East.0.03%他克莫司软膏局部治疗中东地区儿童难治性春季角结膜炎的疗效
Saudi J Ophthalmol. 2019 Apr-Jun;33(2):117-120. doi: 10.1016/j.sjopt.2019.04.001. Epub 2019 May 17.
3
New Therapies and Immunological Findings in Cutaneous T-Cell Lymphoma.皮肤T细胞淋巴瘤的新疗法与免疫学发现
Front Oncol. 2018 Jun 4;8:198. doi: 10.3389/fonc.2018.00198. eCollection 2018.
4
Regulation of HLA-DR peptide occupancy by histone deacetylase inhibitors.组蛋白去乙酰化酶抑制剂对 HLA-DR 肽占据的调控。
Hum Vaccin Immunother. 2013 Apr;9(4):784-9. doi: 10.4161/hv.23085. Epub 2013 Jan 17.
5
Vorinostat approved in Japan for treatment of cutaneous T-cell lymphomas: status and prospects.伏立诺他在日本获批用于治疗皮肤T细胞淋巴瘤：现状与前景
Onco Targets Ther. 2012;5:67-76. doi: 10.2147/OTT.S23874. Epub 2012 Apr 27.
本文引用的文献
1
Topical methyl aminolaevulinate-photodynamic therapy in erosive facial mycosis fungoides.外用甲基氨基乙酰丙酸光动力疗法治疗糜烂性面部蕈样霉菌病
Br J Dermatol. 2010 Oct;163(4):884-5. doi: 10.1111/j.1365-2133.2010.09898.x.
2
Total skin electron beam and non-myeloablative allogeneic hematopoietic stem-cell transplantation in advanced mycosis fungoides and Sezary syndrome.全身电子束照射与非清髓性异基因造血干细胞移植治疗晚期蕈样霉菌病和 Sezary 综合征。
J Clin Oncol. 2010 May 10;28(14):2365-72. doi: 10.1200/JCO.2009.25.8301. Epub 2010 Mar 29.
3
Evaluation of the long-term tolerability and clinical benefit of vorinostat in patients with advanced cutaneous T-cell lymphoma.伏立诺他治疗晚期皮肤T细胞淋巴瘤患者的长期耐受性及临床获益评估。
Clin Lymphoma Myeloma. 2009 Dec;9(6):412-6. doi: 10.3816/CLM.2009.n.082.
4
Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma.多机构二期临床试验：组蛋白去乙酰化酶抑制剂罗米地辛单药治疗皮肤 T 细胞淋巴瘤。
J Clin Oncol. 2009 Nov 10;27(32):5410-7. doi: 10.1200/JCO.2008.21.6150. Epub 2009 Oct 13.
5
Phase II-I-II study of two different doses and schedules of pralatrexate, a high-affinity substrate for the reduced folate carrier, in patients with relapsed or refractory lymphoma reveals marked activity in T-cell malignancies.对复发或难治性淋巴瘤患者开展的一项关于普拉曲沙（还原型叶酸载体的高亲和力底物）两种不同剂量及给药方案的II-I-II期研究显示，其在T细胞恶性肿瘤中具有显著活性。
J Clin Oncol. 2009 Sep 10;27(26):4357-64. doi: 10.1200/JCO.2008.20.8470. Epub 2009 Aug 3.
6
Safety of a new, single, integrated, closed photopheresis system in patients with cutaneous T-cell lymphoma.一种新型单一集成封闭式光分离置换系统用于皮肤T细胞淋巴瘤患者的安全性
Br J Dermatol. 2009 Jul;161(1):167-9. doi: 10.1111/j.1365-2133.2009.09081.x. Epub 2009 Mar 9.
7
Long-term follow-up of photodynamic therapy for mycosis fungoides.蕈样肉芽肿光动力疗法的长期随访
Acta Derm Venereol. 2008;88(3):288-90. doi: 10.2340/00015555-0409.
8
Haematopoietic stem cell transplantation for patients with primary cutaneous T-cell lymphoma.原发性皮肤T细胞淋巴瘤患者的造血干细胞移植
Bone Marrow Transplant. 2008 Apr;41(7):597-604. doi: 10.1038/sj.bmt.1705968. Epub 2008 Jan 7.
9
Subcutaneous alemtuzumab for Sézary Syndrome in the very elderly.
Leuk Res. 2008 Aug;32(8):1299-303. doi: 10.1016/j.leukres.2007.11.009. Epub 2007 Dec 21.
10
Phase II trial of proteasome inhibitor bortezomib in patients with relapsed or refractory cutaneous T-cell lymphoma.蛋白酶体抑制剂硼替佐米用于复发或难治性皮肤T细胞淋巴瘤患者的II期试验。
J Clin Oncol. 2007 Sep 20;25(27):4293-7. doi: 10.1200/JCO.2007.11.4207. Epub 2007 Aug 20.
Zotero 插件