Eroğlu Serpil, Sade Leyla Elif, Aydinalp Alp, Yildirir Aylin, Bozbaş Huseyin, Ulubay Gaye, Muderrisoğlu Haldun
Department of Cardiology, University of Baskent, Faculty of Medicine, Ankara, Turkey.
Acta Cardiol. 2011 Apr;66(2):181-7. doi: 10.1080/ac.66.2.2071249.
Patients with normal ejection fraction (EF) by conventional echocardiography may present with symptoms and findings of decreased cardiac functional capacity. We aimed to investigate the association between cardiac functional capacity determined by cardiopulmonary exercise test (CPET) and parameters of tissue Doppler (TD) imaging in patients with normal EF.
In all, 52 patients with normal EF were included. Conventional and TD imaging were performed. Peak systolic (S), early (E') and late (A') diastolic velocities were obtained from septal and lateral mitral annulus and tricuspid annulus by pulsed-wave TD. CPET was performed. Exercise time, peak oxygen consumption (peak VO2), anaerobic threshold (AT), metabolic equivalents (MET) values were determined and were compared with TD imaging parameters.
We did not find any association between conventional echocardiographic measurements and cardiac functional capacity. However, peak S, E' and A velocity from the septal and tricuspid annulus and E' velocity from the lateral annulus correlated with exercise time, peak VO2, AT and MET (all P < 0.05). E/E' from the left ventricle correlated inversely with exercise time, peak VO2, AT and MET (all P < 0.05). S, E, A' velocities from septal and tricuspid annulus, E' velocity from lateral annulus were lower in patients with MET < or = 7 than in patients with MET > 7 (all P < 0.05).
Systolic and diastolic velocities measured byTD imaging correlated with cardiac functional capacity as determined by CPET in patients with normal EF by conventional echocardiography. TD imaging could be more susceptible to determine cardiac functional capacity in these patients.
经传统超声心动图检查射血分数（EF）正常的患者可能出现心功能容量下降的症状和表现。我们旨在研究心肺运动试验（CPET）测定的心功能容量与EF正常患者组织多普勒（TD）成像参数之间的关联。
共纳入52例EF正常的患者。进行了传统成像和TD成像。通过脉冲波TD从间隔和外侧二尖瓣环以及三尖瓣环获取收缩期峰值（S）、舒张早期（E'）和晚期（A'）速度。进行CPET。测定运动时间、峰值耗氧量（峰值VO2）、无氧阈值（AT）、代谢当量（MET）值，并与TD成像参数进行比较。
我们未发现传统超声心动图测量值与心功能容量之间存在任何关联。然而，间隔和三尖瓣环的峰值S、E'和A速度以及外侧环E'速度与运动时间、峰值VO2、AT及MET相关（均P<0.05）。左心室E/E'与运动时间、峰值VO2、AT及MET呈负相关（均P<0.05） 。MET≤7患者的间隔和三尖瓣环S、E、A'速度以及外侧环E'速度低于MET>7的患者（均P<0.05）。
在经传统超声心动图检查EF正常的患者中，TD成像测量的收缩期和舒张期速度与CPET测定的心功能容量相关。TD成像在这些患者中可能更易于测定心功能容量。
