水结合折叠体对常规和非常规水二聚体的包裹。

Encapsulation of conventional and unconventional water dimers by water-binding foldamers.

机构信息

Department of Chemistry and NUS MedChem Program of the Office of Life Sciences, 3 Science Drive 3, National University of Singapore, Singapore 117543.

出版信息

Org Lett. 2011 Jun 17;13(12):3194-7. doi: 10.1021/ol2011083. Epub 2011 May 18.

DOI:10.1021/ol2011083

PMID:21591725

Abstract

Water-binding foldamers have been rarely studied. By orienting both H-bond donors and acceptors toward their interior, two pyridine-derived crescent-shaped folding oligoamides were found to be capable of trapping both conventional and unconventional water dimer clusters in their cavity (∼2.5 Å radius). In the unconventional water dimer cluster, the two water molecules stay in contact via an unusual H-H interaction (2.25 Å) rather than the typical H-bond.

摘要

水结合折叠体的研究很少。通过将氢键供体和受体都朝向其内部取向，发现两个源自吡啶的新月形折叠寡聚酰胺能够在其腔（半径约为 2.5 Å）中捕获常规和非常规的水分子二聚体簇。在非常规的水分子二聚体簇中，两个水分子通过不寻常的 H-H 相互作用（2.25 Å）而不是典型的氢键保持接触。