Mori K, Ohnishi A, Fujishiro K, Inoue N
Department of Environmental Toxicology, University of Occupational and Environmental Health, Kitakyushu, Japan.
J UOEH. 1990 Mar 1;12(1):61-6. doi: 10.7888/juoeh.12.61.
Male and female Wistar rats were exposed to ethylene oxide (EO) at a concentration of 250 ppm, 6 hours a day, 5 days a week for 17 weeks simultaneously, and the sexual difference in susceptibility of the peripheral nerve to EO was investigated. Both male and female rats of the exposed group showed paresis of the hindlegs, but sexual difference did not affect the degree of this abnormality. In histopathological examinations, axonal degeneration of the myelinated fibers in the peroneal nerve, the nerve to the soleus muscle and in the gracile fascicles of the spinal cord was revealed. The nerve to the soleus muscle degenerated more severely than the peroneal nerve. Sexual difference played no part in the severity of the degenerations in each nerve or in the gracile fascicles. From these observations, we concluded that there was no significant difference in the susceptibility of the peripheral nerve to EO between male and female rats.
将雄性和雌性Wistar大鼠同时暴露于浓度为250 ppm的环氧乙烷（EO）中，每天6小时，每周5天，持续17周，研究外周神经对EO易感性的性别差异。暴露组的雄性和雌性大鼠均出现后肢麻痹，但性别差异并未影响这种异常的程度。在组织病理学检查中，发现腓总神经、比目鱼肌神经和脊髓薄束中的有髓纤维轴突变性。比目鱼肌神经的变性比腓总神经更严重。性别差异在各神经或薄束变性的严重程度中不起作用。从这些观察结果来看，我们得出结论，雄性和雌性大鼠外周神经对EO的易感性没有显著差异。
