Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai, Tamil Nadu, India.
Pharm Biol. 2011 Oct;49(10):1074-81. doi: 10.3109/13880209.2011.565477. Epub 2011 May 18.
Ichnocarpus frutescens (L.) R.Br. (Apocynaceae) is used to treat diabetes and hyperlipidemia in folk medicine.
The crude methanol extract and fractions of I. frutescens were investigated for antihyperlipidemic effect.
Fresh leaves of I. frutescens were extracted with methanol and fractionated with hexane, benzene, ethyl acetate, acetone, and methanol. The active acetone fraction was subfractionated, which resulted in active fraction 3. The antihyperlipidemic effects of the methanol extract and fractions of I. frutescens were studied in triton WR-1339-induced and high-fat diet (HFD) obese animals. Further, lipid absorption and excretion were studied.
The methanol extract significantly reduced total cholesterol (TC) by 29.63% and triglyceride (Tg) by 51.10% at 400 mg/kg in triton WR-1339-induced animals and significantly reduced TC (27.81%) and Tg (37.03%) at 400 mg/kg in HFD animals. Fraction 3 showed significant reduction in TC (25.03%) and Tg (58.05%) at 200 mg/kg. Feeding of HFD consisting 3% of fraction 3 increased feces weight and Tg level in mice. Fraction 3, showed significant decrease in plasma Tg level at the second hour, after oral administration of the lipid emulsion to rats.
The observed properties apparently validate the folk medicinal use of this plant in amelioration of hyperlipidemia.
鸡骨常山（L.）R.Br.（夹竹桃科）在民间医学中用于治疗糖尿病和高血脂症。
研究鸡骨常山的粗甲醇提取物和馏分的降血脂作用。
用甲醇提取鸡骨常山的新鲜叶片，并分别用己烷、苯、乙酸乙酯、丙酮和甲醇进行馏分。将活性的丙酮馏分进行亚馏分分离，得到活性 3 部分。研究鸡骨常山甲醇提取物和馏分对 Triton WR-1339 诱导和高脂肪饮食（HFD）肥胖动物的降血脂作用。此外，还研究了脂质吸收和排泄。
甲醇提取物在 Triton WR-1339 诱导的动物中以 400mg/kg 的剂量显著降低总胆固醇（TC）29.63%和三酰甘油（Tg）51.10%，在 HFD 动物中以 400mg/kg 的剂量显著降低 TC（27.81%）和 Tg（37.03%）。馏分 3 在 200mg/kg 时显示出 TC（25.03%）和 Tg（58.05%）的显著降低。喂食含 3%馏分 3 的 HFD 增加了小鼠粪便重量和 Tg 水平。馏分 3 在给大鼠口服脂肪乳剂后的第二个小时显著降低血浆 Tg 水平。
观察到的特性显然验证了民间医学中使用该植物改善高血脂症的用途。
