Faculty of Medicine, Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
Platelets. 2011;22(7):552-6. doi: 10.3109/09537104.2011.578182. Epub 2011 May 19.
Previous studies have reported increased platelet activation and aggregation in patients with obstructive sleep apnea (OSA). Continuous positive airway pressure (CPAP) treatment has been shown to decrease platelet activation. We aimed to study the effects of nasal CPAP therapy has on MPV values in patients with severe OSA. Thirty-one patients (21 men; mean age 53.8 ± 9.2 years) with severe OSA (AHI > 30 events/hour) constituted the study group. An age, gender and body mass index (BMI) matched control group was composed 25 subjects (14 men; mean age 49.6 ± 8.5 years) without OSA (AHI < 5 events/hour). We measured MPV values in patients with severe OSA and control subjects and we measured MPV values after 6 months of CPAP therapy in severe OS patients. The median (IQR) MPV values were significantly higher in patients with severe OSA than in control group (8.5 [8.3-9.1] vs. 8.3 [7.5-8.8] fL; p = 0.03). The platelet counts were significantly lower in patients with severe OSA than in control group (217.8 ± 45.9 vs. 265.4 ± 64.0 × 10⁹/L; p = 0.002). The six months of CPAP therapy caused significant reductions in median (IQR) MPV values in patients with severe OSA (8.5 [8.3-9.1] to 7.9 [7.4-8.2] fL; p < 0.001). Six months of CPAP therapy caused significant increase in platelet counts when compared with baseline values (217.8 ± 45.9 to 233.7 ± 60.6 × 10⁹/L; p < 0.001). We have found that the MPV values of patients with severe OSA were significantly higher than those of the control subjects and 6 months CPAP therapy caused significant reductions in the MPV values in patients with severe OSA.
先前的研究报告表明，阻塞性睡眠呼吸暂停（OSA）患者的血小板活化和聚集增加。持续气道正压通气（CPAP）治疗已被证明可降低血小板活化。我们旨在研究鼻 CPAP 治疗对严重 OSA 患者的 MPV 值的影响。31 例（21 名男性；平均年龄 53.8±9.2 岁）严重 OSA（AHI>30 次/小时）患者为研究组。年龄、性别和体重指数（BMI）匹配的对照组由 25 名无 OSA（AHI<5 次/小时）患者组成（14 名男性；平均年龄 49.6±8.5 岁）。我们测量了严重 OSA 患者和对照组患者的 MPV 值，并在严重 OSA 患者接受 CPAP 治疗 6 个月后测量了 MPV 值。严重 OSA 患者的中位数（IQR）MPV 值明显高于对照组（8.5[8.3-9.1]vs.8.3[7.5-8.8]fl；p=0.03）。严重 OSA 患者的血小板计数明显低于对照组（217.8±45.9vs.265.4±64.0×10⁹/L；p=0.002）。CPAP 治疗 6 个月可显著降低严重 OSA 患者的中位数（IQR）MPV 值（8.5[8.3-9.1]至 7.9[7.4-8.2]fl；p<0.001）。与基线值相比，CPAP 治疗 6 个月可显著增加血小板计数（217.8±45.9 至 233.7±60.6×10⁹/L；p<0.001）。我们发现，严重 OSA 患者的 MPV 值明显高于对照组，6 个月 CPAP 治疗可显著降低严重 OSA 患者的 MPV 值。
