来自巴西南部和东南部地区合并感染HIV患者的人类嗜T淋巴细胞病毒1型（HTLV-1）分离株的系统发育和相似性分析。
Phylogenetic and similarity analysis of HTLV-1 isolates from HIV-coinfected patients from the south and southeast regions of Brazil.
作者信息
Magri Mariana Cavalheiro, Brigido Luis Fernando de Macedo, Rodrigues Rosangela, Morimoto Helena Kaminami, Ferreira João Leandro de Paula, Caterino-de-Araujo Adele
机构信息
Laboratório de Retrovirus, Centro de Virologia, Instituto Adolfo Lutz, Secretaria de Estado da Saúde de São Paulo, Brazil.
出版信息
AIDS Res Hum Retroviruses. 2012 Jan;28(1):110-4. doi: 10.1089/AID.2011.0117. Epub 2011 Jun 24.
Abstract
HTLV-1 is endemic in Brazil and HIV/HTLV-1 coinfection has been detected, mostly in the northeast region. Cosmopolitan HTLV-1a is the main subtype that circulates in Brazil. This study characterized 17 HTLV-1 isolates from HIV coinfected patients of southern (n=7) and southeastern (n=10) Brazil. HTLV-1 provirus DNA was amplified by nested PCR (env and LTR) and sequenced. Env sequences (705 bp) from 15 isolates and LTR sequences (731 bp) from 17 isolates showed 99.5% and 98.8% similarity among sequences, respectively. Comparing these sequences with ATK (HTLV-1a) and Mel5 (HTLV-1c) prototypes, similarities of 99% and 97.4%, respectively, for env and LTR with ATK, and 91.6% and 90.3% with Mel5, were detected. Phylogenetic analysis showed that all sequences belonged to the transcontinental subgroup A of the Cosmopolitan subtype, clustering in two Latin American clusters.
摘要
人类嗜T淋巴细胞病毒1型（HTLV-1）在巴西呈地方性流行，且已检测到HIV/HTLV-1合并感染，主要集中在东北地区。世界流行的HTLV-1a是在巴西传播的主要亚型。本研究对来自巴西南部（n = 7）和东南部（n = 10）的HIV合并感染患者的17株HTLV-1分离株进行了特征分析。通过巢式PCR（env和LTR）扩增HTLV-1前病毒DNA并进行测序。15株分离株的env序列（705 bp）和17株分离株的LTR序列（731 bp）在序列间的相似性分别为99.5%和98.8%。将这些序列与ATK（HTLV-1a）和Mel5（HTLV-1c）原型进行比较，发现env和LTR与ATK的相似性分别为99%和97.4%，与Mel5的相似性分别为91.6%和90.3%。系统发育分析表明，所有序列均属于世界流行亚型的跨大陆A亚组，聚集在两个拉丁美洲簇中。
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