HTLV1 感染与肝功能和血脂指标的长期关联；10 年随访。

HTLV1 infection and long term association with liver function and lipid indices; 10 years' follow-up.

机构信息

Student Research Committee, Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

BMC Infect Dis. 2024 Sep 28;24(1):1067. doi: 10.1186/s12879-024-09980-z.

DOI:10.1186/s12879-024-09980-z

PMID:39342192

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11439208/

Abstract

BACKGROUND

Human T-cell leukemia virus type 1 (HTLV-1) is a well-known retrovirus, particularly prevalent in northeastern Iran, where it is associated with a range of disorders, including liver dysfunction. Previous studies have demonstrated that HTLV-1 infection can alter lipid profiles, yet no research has examined lipid indices and liver function tests in these patients in the long term.

METHODS

This data is part of the Mashhad stroke and heart atherosclerotic disorder (MASHAD) study. A total of 1116 participants were randomly selected, including 837 healthy individuals and 279 HTLV-1-infected patients. Following a 10-year follow-up period, Serum levels of liver enzymes were measured. Lipid indices such as the Atherogenic Index of Plasma (AIP), Body Adiposity Index (BAC), Castelli risk index (CRI-I, CRI-II), Lipid Accumulation Product (LAP), Visceral Adiposity Index (VAI), Triglyceride-glucose index (TyG), and Triglyceride and HDL-C Ratio (THR) were calculated.

RESULTS

Multivariable-adjusted regression analysis demonstrated a significant coefficient for the Visceral Adiposity Index (VAI) in HTLV-infected patients compared to healthy controls (B: -0.014, 95% CI: -0.02, 0.00, p = 0.046). However, no significant differences were observed in other lipid indices between HTLV-infected patients and healthy individuals. Regarding liver enzymes, significant variations were noted in HTLV-infected patients compared to healthy controls: Aspartate Aminotransferase (AST) (B: 2.978, 95% CI: 1.34, 4.61, p < 0.001), Alanine Aminotransferase (ALT) (B: 3.687, 95% CI: 1.59, 5.78, p = 0.001), Alkaline Phosphatase (ALP) (B: 18.232, 95% CI: 6.81, 29.65, p = 0.002), and Gamma-Glutamyl Transferase (GGT) (B: 3.714, 95% CI: 0.18, 7.24, p = 0.039).

CONCLUSION

Individuals with HTLV-1 infection exhibit reduced VAI but elevated levels of liver enzymes such as AST, ALT, ALP, and GGT, indicating liver damage. These findings emphasize the virus's involvement in liver pathology. Also, HTLV-I is associated with reduced visceral fat tissue.

摘要

背景

人类 T 细胞白血病病毒 1 型（HTLV-1）是一种众所周知的逆转录病毒，在伊朗东北部尤为流行，与一系列疾病有关，包括肝功能障碍。先前的研究表明，HTLV-1 感染会改变脂质谱，但没有研究在长期内检查这些患者的脂质指数和肝功能试验。

方法

本数据来自马什哈德中风和心脏动脉粥样硬化紊乱（MASHAD）研究。共随机选择了 1116 名参与者，包括 837 名健康个体和 279 名 HTLV-1 感染患者。在 10 年的随访期间，测量了血清肝酶水平。计算了载脂蛋白指数（AIP）、体脂指数（BAC）、卡斯特利风险指数（CRI-I、CRI-II）、脂质蓄积产物（LAP）、内脏脂肪指数（VAI）、甘油三酯-葡萄糖指数（TyG）和甘油三酯与高密度脂蛋白胆固醇比值（THR）等脂质指数。

结果

多变量调整回归分析显示，与健康对照组相比，HTLV 感染患者的内脏脂肪指数（VAI）具有显著的系数（B：-0.014，95%CI：-0.02，0.00，p=0.046）。然而，HTLV 感染患者与健康个体之间的其他脂质指数没有显著差异。至于肝酶，与健康对照组相比，HTLV 感染患者有显著变化：天门冬氨酸氨基转移酶（AST）（B：2.978，95%CI：1.34，4.61，p<0.001）、丙氨酸氨基转移酶（ALT）（B：3.687，95%CI：1.59，5.78，p=0.001）、碱性磷酸酶（ALP）（B：18.232，95%CI：6.81，29.65，p=0.002）和γ-谷氨酰转移酶（GGT）（B：3.714，95%CI：0.18，7.24，p=0.039）。