Nankervis Helen, Maplethorpe Alan, Williams Hywel C
Centre of Evidence Based Dermatology, Room A103, King's Meadow Campus, University of Nottingham, Lenton Lane, Nottingham, NG7 2NR, UK.
BMC Dermatol. 2011 May 18;11:10. doi: 10.1186/1471-5945-11-10.
Massive duplication of effort occurs when researchers all over the world undertake extensive searches for randomized controlled trials when preparing systematic reviews, when developing evidence-based guidelines and when applying for research funding for eczema treatments. Such duplication wastes valuable resources.Searching for randomized controlled trials of eczema is a laborious task involving scrutiny of thousands of individual references from diverse electronic databases in order to obtain a few papers of interest. Clinicians and patients who wish to find out more about a particular treatment are at risk of missing the relevant evidence if they are not trained in electronic bibliographic searching. Systematic reviews cannot be relied upon to comprehensively inform current optimal eczema treatments due to incomplete coverage and because many may be out of date.An international, publically available and comprehensive resource which brings together all randomized controlled trials on eczema treatment using a highly sensitive search has the potential to release more filtered knowledge about patient care to those who need it most and to significantly shorten the duration and costs of many clinical eczema research and guideline projects.
The Global Resource of EczemA Trials brings together information on all randomized controlled trials of eczema treatments published from the beginning of 2000 up to the end of 2010 and will be updated every month.We searched the Cochrane Central Register of Controlled Trials in The Cochrane Library and the Cochrane Skin Group Specialised Register, MEDLINE, EMBASE, LILACS, AMED and CINHAL databases. We included 268 RCTs (24th March 2011) covering over 70 different treatment interventions.The structure of the Global Resource of Eczema Trials allows the user as much, or as little, specificity when retrieving information on trials as they wish, in an easy to use format. For each trial, the database gives the citation for the published report and also provides enough information to enable a user to decide whether the trial is worth further scrutiny.
The Global Resource of Eczema Trials has been created to facilitate knowledge mobilization into healthcare and to reduce wastage of research time through unnecessary duplication. The collective time saved by research groups around the world can now be used to make strides in optimising the treatment of eczema, in order to further benefit people with eczema. The database can be accessed free of charge at http://www.greatdatabase.org.uk.
当世界各地的研究人员在准备系统评价、制定循证指南以及申请湿疹治疗研究资金时，都要进行广泛的随机对照试验检索，这会出现大量的重复劳动。这种重复浪费了宝贵的资源。检索湿疹的随机对照试验是一项艰巨的任务，需要仔细审查来自各种电子数据库的数千条参考文献，才能获得几篇感兴趣的论文。如果临床医生和患者没有接受过电子文献检索培训，他们想要了解更多关于特定治疗方法的信息时，就有可能错过相关证据。由于覆盖不全面且许多可能已过时，不能依靠系统评价来全面了解当前最佳的湿疹治疗方法。一个国际性的、公开可用的综合资源，汇集了所有使用高灵敏度检索的湿疹治疗随机对照试验，有可能将更多经过筛选的患者护理知识传递给最需要的人，并显著缩短许多临床湿疹研究和指南项目的时间和成本。
全球湿疹试验资源汇集了2000年初至2010年底发表的所有湿疹治疗随机对照试验的信息，并将每月更新。我们检索了Cochrane图书馆中的Cochrane对照试验中心注册库、Cochrane皮肤小组专业注册库、MEDLINE、EMBASE、LILACS、AMED和CINHAL数据库。我们纳入了268项随机对照试验（2011年3月24日），涵盖70多种不同的治疗干预措施。全球湿疹试验资源的结构允许用户在检索试验信息时根据自己的意愿选择或多或少的特异性，采用易于使用的格式。对于每项试验，数据库给出已发表报告的引用，并提供足够的信息，以便用户决定该试验是否值得进一步审查。
创建全球湿疹试验资源是为了促进知识向医疗保健领域的传播，并通过避免不必要的重复来减少研究时间的浪费。现在，世界各地的研究团队节省下来的总时间可用于在优化湿疹治疗方面取得进展，从而使湿疹患者进一步受益。该数据库可在http://www.greatdatabase.org.uk免费访问。
