特应性皮炎管理指南：第 2 节。特应性皮炎的局部治疗管理和治疗。
Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies.
机构信息
Division of Pediatric and Adolescent Dermatology, University of California, San Diego, California; Rady Children's Hospital, San Diego, California.
Department of Dermatology, University of California, San Francisco, California.
出版信息
J Am Acad Dermatol. 2014 Jul;71(1):116-32. doi: 10.1016/j.jaad.2014.03.023. Epub 2014 May 9.
Abstract
Atopic dermatitis is a common and chronic, pruritic inflammatory skin condition that can affect all age groups. This evidence-based guideline addresses important clinical questions that arise in its management. In this second of 4 sections, treatment of atopic dermatitis with nonpharmacologic interventions and pharmacologic topical therapies are reviewed. Where possible, suggestions on dosing and monitoring are given based on available evidence.
摘要
特应性皮炎是一种常见的慢性、瘙痒性炎症性皮肤病，可影响所有年龄段。本循证指南针对其治疗中出现的重要临床问题。在这 4 个部分中的第 2 部分中，回顾了非药物干预和药物局部治疗特应性皮炎的方法。在可能的情况下，根据现有证据给出了关于剂量和监测的建议。
相似文献
1
Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies.特应性皮炎管理指南：第 2 节。特应性皮炎的局部治疗管理和治疗。
J Am Acad Dermatol. 2014 Jul;71(1):116-32. doi: 10.1016/j.jaad.2014.03.023. Epub 2014 May 9.
2
Atopic dermatitis: skin care and topical therapies.特应性皮炎：皮肤护理与局部治疗
Semin Cutan Med Surg. 2017 Sep;36(3):104-110. doi: 10.12788/j.sder.2017.035.
3
Guidelines of care for the management of atopic dermatitis in adults with topical therapies.成人特应性皮炎局部治疗管理指南。
J Am Acad Dermatol. 2023 Jul;89(1):e1-e20. doi: 10.1016/j.jaad.2022.12.029. Epub 2023 Jan 12.
4
Executive summary: American Academy of Dermatology guidelines of care for the management of atopic dermatitis in adults with topical therapies.执行摘要：美国皮肤病学会关于成人特应性皮炎局部治疗管理的护理指南。
J Am Acad Dermatol. 2023 Jul;89(1):128-129. doi: 10.1016/j.jaad.2022.08.068. Epub 2023 Jan 7.
5
Guidelines for the Management of Atopic Dermatitis in Singapore.新加坡特应性皮炎管理指南。
Ann Acad Med Singap. 2016 Oct;45(10):439-450.
6
Pediatric atopic dermatitis: a review of the medical management.儿童特应性皮炎：医学治疗综述。
Ann Pharmacother. 2010 Sep;44(9):1448-58. doi: 10.1345/aph.1P098. Epub 2010 Jul 13.
7
Clinical management of atopic dermatitis: practical highlights and updates from the atopic dermatitis practice parameter 2012.特应性皮炎的临床管理：2012年特应性皮炎实践参数的实用要点与更新
J Allergy Clin Immunol Pract. 2014 Jul-Aug;2(4):361-9; quiz 370. doi: 10.1016/j.jaip.2014.02.015. Epub 2014 Apr 25.
8
[Not Available].[无可用内容]。
Ann Dermatol Venereol. 2019 Dec;146(12S3):12S85-12S95. doi: 10.1016/S0151-9638(20)30018-1.
9
Prescription Treatment Options.处方治疗选项。
Adv Exp Med Biol. 2017;1027:105-120. doi: 10.1007/978-3-319-64804-0_10.
10
A comparison of international management guidelines for atopic dermatitis.特应性皮炎国际管理指南的比较
Pediatr Dermatol. 2019 Jan;36(1):36-65. doi: 10.1111/pde.13678. Epub 2018 Oct 10.
引用本文的文献
1
Water Extract of Flower Ameliorates Extract-Induced Atopic Dermatitis-like Skin Inflammation by Attenuating JAK/STAT Signaling.花的水提取物通过减弱JAK/STAT信号通路改善提取物诱导的特应性皮炎样皮肤炎症。
Int J Mol Sci. 2025 Jul 22;26(15):7063. doi: 10.3390/ijms26157063.
2
Fatty Acid-Rich Fraction of L. Alleviates Atopic Dermatitis-like Skin Lesions Mouse Model via Inflammatory Pathway Modulation: Integrative Docking and Experimental Validation.罗伊氏乳杆菌富含脂肪酸的组分通过调节炎症途径减轻特应性皮炎样皮肤损伤小鼠模型：综合对接与实验验证
Plants (Basel). 2025 Aug 7;14(15):2447. doi: 10.3390/plants14152447.
3
Exploring Young Adults' Experiences of Atopic Dermatitis Self-Management and Use of Community Pharmacy: A Qualitative Study.探索青年成年人特应性皮炎自我管理及社区药房使用体验：一项定性研究
Health Expect. 2025 Aug;28(4):e70378. doi: 10.1111/hex.70378.
4
Consensus-Based Guidelines for the Treatment of Atopic Dermatitis in Korea (Part I): Basic Therapy, Topical Therapy, and Conventional Systemic Therapy.韩国特应性皮炎治疗的基于共识的指南（第一部分）：基础治疗、局部治疗和传统全身治疗。
Ann Dermatol. 2025 Aug;37(4):201-215. doi: 10.5021/ad.24.153.
5
Investigating the efficacy of dipotassium glycyrrhizin emollients in adult atopic dermatitis: A focused randomized parallel-controlled clinical study.研究甘草酸二钾润肤剂在成人特应性皮炎中的疗效：一项聚焦的随机平行对照临床研究。
Pak J Med Sci. 2025 Jul;41(7):1937-1942. doi: 10.12669/pjms.41.7.9559.
6
The Influence of Moisturizer Co-Application Protocols on In Vitro Penetration of Betamethasone in Porcine Skin.保湿剂联合应用方案对倍他米松在猪皮肤中体外渗透的影响
Pharmaceutics. 2025 Jul 3;17(7):874. doi: 10.3390/pharmaceutics17070874.
7
Assessment of the quality of life in patients with atopic dermatitis using the Kazakh version of the questionnaire "Dermatology Life Quality Index".使用哈萨克语版“皮肤病生活质量指数”问卷评估特应性皮炎患者的生活质量。
Asia Pac Allergy. 2025 Jun;15(2):49-56. doi: 10.5415/apallergy.0000000000000183. Epub 2025 Feb 5.
8
Methotrexate in the treatment of atopic dermatitis.甲氨蝶呤治疗特应性皮炎
Postepy Dermatol Alergol. 2025 Apr 15;42(3):243-247. doi: 10.5114/ada.2025.149551. eCollection 2025 Jun.
9
Emerging trends and research hotspots in atopic dermatitis-related itch over the past 10 years: a bibliometric and visual analysis.过去10年特应性皮炎相关瘙痒的新兴趋势和研究热点：文献计量学与可视化分析
Front Med (Lausanne). 2025 Jun 17;12:1503312. doi: 10.3389/fmed.2025.1503312. eCollection 2025.
10
Advances in Transdermal Drug Delivery Systems and Clinical Applications in Inflammatory Skin Diseases.经皮给药系统的进展及其在炎症性皮肤病中的临床应用
Pharmaceutics. 2025 Jun 6;17(6):746. doi: 10.3390/pharmaceutics17060746.
本文引用的文献
1
Atopic dermatitis: a practice parameter update 2012.特应性皮炎：2012 年实践参数更新。
J Allergy Clin Immunol. 2013 Feb;131(2):295-9.e1-27. doi: 10.1016/j.jaci.2012.12.672.
2
Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis.煤焦油诱导特应性皮炎中 AHR 依赖性皮肤屏障修复。
J Clin Invest. 2013 Feb;123(2):917-27. doi: 10.1172/JCI65642. Epub 2013 Jan 25.
3
Guidelines for treatment of atopic eczema (atopic dermatitis) Part II.特应性皮炎（特应性湿疹）治疗指南（二）。
J Eur Acad Dermatol Venereol. 2012 Sep;26(9):1176-93. doi: 10.1111/j.1468-3083.2012.04636.x. Epub 2012 Jul 19.
4
Guidelines for treatment of atopic eczema (atopic dermatitis) part I.特应性皮炎（特应性湿疹）治疗指南 第一部分。
J Eur Acad Dermatol Venereol. 2012 Aug;26(8):1045-60. doi: 10.1111/j.1468-3083.2012.04635.x.
5
Safety and tolerability of a body wash and moisturizer when applied to infants and toddlers with a history of atopic dermatitis: results from an open-label study.一款沐浴露和保湿霜应用于有特应性皮炎病史的婴幼儿时的安全性和耐受性：一项开放标签研究的结果
Pediatr Dermatol. 2012 Sep-Oct;29(5):590-7. doi: 10.1111/j.1525-1470.2012.01809.x. Epub 2012 Jul 8.
6
Comparative effectiveness of topical calcineurin inhibitors in adult patients with atopic dermatitis.成人特应性皮炎患者中局部钙调磷酸酶抑制剂的疗效比较。
Am J Clin Dermatol. 2012 Apr 1;13(2):113-23. doi: 10.2165/11597780-000000000-00000.
7
Wet dressing therapy in conjunction with topical corticosteroids is effective for rapid control of severe pediatric atopic dermatitis: experience with 218 patients over 30 years at Mayo Clinic.湿性敷料疗法联合局部皮质类固醇治疗对迅速控制严重儿童特应性皮炎有效：梅奥诊所 30 年来 218 例患者的经验。
J Am Acad Dermatol. 2012 Jul;67(1):100-6. doi: 10.1016/j.jaad.2011.06.025. Epub 2011 Oct 5.
8
Mapping randomized controlled trials of treatments for eczema--the GREAT database (the Global Resource of EczemA Trials: a collection of key data on randomized controlled trials of treatments for eczema from 2000 to 2010).绘制湿疹治疗随机对照试验图谱——GREAT数据库（全球湿疹试验资源：2000年至2010年湿疹治疗随机对照试验关键数据集合）
BMC Dermatol. 2011 May 18;11:10. doi: 10.1186/1471-5945-11-10.
9
An over-the-counter moisturizer is as clinically effective as, and more cost-effective than, prescription barrier creams in the treatment of children with mild-to-moderate atopic dermatitis: a randomized, controlled trial.一项随机对照试验表明：在治疗轻至中度特应性皮炎儿童时，非处方保湿霜在临床效果上与处方屏障乳膏相当，且更具成本效益。
J Drugs Dermatol. 2011 May;10(5):531-7.
10
Evaluation of cancer risk related to atopic dermatitis and use of topical calcineurin inhibitors.评估特应性皮炎与使用局部钙调磷酸酶抑制剂相关的癌症风险。
Br J Dermatol. 2011 Sep;165(3):465-73. doi: 10.1111/j.1365-2133.2011.10363.x. Epub 2011 Jun 30.
Zotero 插件