Department of Traumatology, University of Newcastle and John Hunter Hospital, Newcastle, NSW, Australia.
Injury. 2012 Feb;43(2):169-73. doi: 10.1016/j.injury.2011.04.011. Epub 2011 May 17.
The importance of the abdominal wall characteristics in intraabdominal pressure (IAP), intraabdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are poorly understood. The applicability of laboratory research findings to human scenarios is unknown due to the potential differences in abdominal wall elastance (AWE) amongst species. The aims of the study are to describe the AWE curve in rabbits and to compare it to the available human data.
Prospective experimental animal study in the setting of research laboratory. Male New Zealand White rabbits weighting 2.7 kg ± 0.1 kg, were anesthetized and the AWE was determined by infusion of lactated Ringer's solution into the peritoneal cavity whilst the IAP was measured. A meta-analysis of peer-reviewed studies was conducted to define human AWE.
The described AWE was lower in the rabbit than in humans. The function comparing human and rabbit was: log(e) human IAP = (0.58 log(e) rabbit IAP+1.6).
The AWE can vary amongst species. This study determined the relationship to allow the comparison of rabbit and human IAP. The proposed mathematical function is important for the advancement of interpretation and understanding of animal research into IAH and ACS. We recommend developing model-specific functions comparing individual animal models' IAP and that of humans.
腹壁特征在腹腔内压（IAP）、腹腔高压（IAH）和腹腔间隔室综合征（ACS）中的重要性尚未被充分理解。由于物种之间腹壁弹性（AWE）存在潜在差异，实验室研究结果在人类中的适用性尚不清楚。本研究旨在描述兔的 AWE 曲线，并将其与现有的人类数据进行比较。
在研究实验室的背景下进行前瞻性实验动物研究。体重为 2.7kg±0.1kg 的雄性新西兰白兔，麻醉后通过向腹腔内输注乳酸林格氏液来确定 AWE，同时测量 IAP。对同行评议的研究进行荟萃分析，以确定人类的 AWE。
兔的 AWE 低于人类。比较人类和兔的函数为：log(e) 人类 IAP = (0.58 log(e) 兔 IAP+1.6)。
AWE 可能在不同物种之间有所差异。本研究确定了这种关系，以允许比较兔和人类的 IAP。所提出的数学函数对于解释和理解 IAH 和 ACS 动物研究具有重要意义。我们建议针对每个动物模型的 IAP 制定特定模型的函数，并与人类进行比较。
