Chen Yu, Xue Xiang, Wang Li, Jin Chunhua, Zou Yantai
Teaching Center of Experimental Medicine, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2012 Sep;32(9):1312-5.
To establish a rabbit model of abdominal compartment syndrome (ACS) and evaluate the impact of ACS on cardiovascular and respiratory functions and blood electrolyte levels in rabbits.
Twenty-four New Zealand rabbits were randomly allocated into 4 equal groups, namely the normal control group, ACS(5>) group [intra-abdominal pressure (IAP)=5 mmHg], ACS(10) group (IAP=10 mmHg) and ACS(20) group (IAP=20 mmHg). ACS model was established by intra- abdominal bleeding (IAB) with intra-abdominal hypertension (IAH). All the data were recorded 1 h after inducing IAH including cardiovascular parameters (LVSP, LVEDP, ∓dp/dt max, SP, DP, HR, CVP), respiratory function (RR, PaO(2), PaCO(2), [HCO(3)(-)]), blood pH, and electrolyte level ([K(+)]).
Compared with those in the normal control group, ACS20 group showed significantly decreased LVSP, LVEDP, ∓dp/dt max, SP, DP, HR, RR, PaO(2), [HCO(3)(-)], and blood pH but increased CVP, PaCO(2), and K(+) (P<0.05). In ACS(10) group, all the parameters except for RR and PaO(2) showed similar changes as seen in ACS(20) group (P<0.05) but with lower amplitudes of variations. In ACS(5) group, only LVSP and HR were reduced remarkably (P<0.05) while the other parameters showed no significant variations.
IAB plus IAH may cause damage to the cardiovascular and respiratory functions and lead to ACS in rabbits.
建立兔腹腔间隔室综合征（ACS）模型，评估ACS对兔心血管和呼吸功能以及血液电解质水平的影响。
将24只新西兰兔随机分为4组，每组6只，即正常对照组、ACS（5）组[腹腔内压（IAP）=5 mmHg]、ACS（10）组（IAP = 10 mmHg）和ACS（20）组（IAP = 20 mmHg）。通过腹腔内出血（IAB）合并腹腔内高压（IAH）建立ACS模型。在诱导IAH 1小时后记录所有数据，包括心血管参数（左心室收缩压、左心室舒张末压、±dp/dt max、收缩压、舒张压、心率、中心静脉压）、呼吸功能（呼吸频率、动脉血氧分压、动脉血二氧化碳分压、[HCO₃⁻]）、血液pH值和电解质水平（[K⁺]）。
与正常对照组相比，ACS20组的左心室收缩压、左心室舒张末压、±dp/dt max、收缩压、舒张压、心率、呼吸频率、动脉血氧分压、[HCO₃⁻]和血液pH值显著降低，但中心静脉压、动脉血二氧化碳分压和[K⁺]升高（P<0.05）。在ACS（10）组中，除呼吸频率和动脉血氧分压外，所有参数的变化与ACS（20）组相似（P<0.05），但变化幅度较小。在ACS（5）组中，仅左心室收缩压和心率显著降低（P<0.05），而其他参数无明显变化。
IAB加IAH可能导致兔心血管和呼吸功能损害并引发ACS。
