Unidad de Reactivos y Biomodelos de Experimentación, Facultad de Medicina, Universidad de la República (UDELAR), Uruguay.
Vet Parasitol. 2011 Sep 27;181(2-4):341-4. doi: 10.1016/j.vetpar.2011.04.011. Epub 2011 Apr 15.
The aim of this work was to evaluate the potential of lufenuron, a benzylphenylurea with ability to interfere with the formation of insect exoskeleton, as a therapeutic drug for larval echinococcosis (hydatid disease). For this purpose lufenuron, alone or in combination with albendazole, was administered to CD1 mice bearing Echinococcus granulosus hydatid cysts in the peritoneal cavity. Neither of the drugs alone was able to exert parasiticidal effects. However, in combination with albendazole, lufenuron reduced the growth of cysts (30-40% in cyst diameter respect to control, p<0.05). This effect was associated with ultrastructural alterations of the hydatid cyst wall and a reduction of the content of myo-inositol-hexakisphosphate, the major component of the electron dense granules of the laminated layer. Overall, this work provides evidence that lufenuron could represent a useful compound for the use in chemotherapy against larval echinococcosis, by enhancing albendazole parasiticidal activity.
本研究旨在评估灭幼脲（一种具有干扰昆虫外骨骼形成能力的苯甲酰基苯脲）作为幼虫棘球蚴病（包虫病）治疗药物的潜力。为此，将灭幼脲单独或与阿苯达唑联合用于腹腔内携带细粒棘球蚴包虫囊肿的 CD1 小鼠。单独使用这两种药物均不能发挥杀虫作用。然而，与阿苯达唑联合使用时，灭幼脲可抑制囊肿生长（囊肿直径相对于对照组减少 30-40%，p<0.05）。这种作用与包虫囊壁的超微结构改变以及电子致密颗粒中主要成分肌醇六磷酸的含量减少有关。综上所述，本研究结果表明，灭幼脲可能通过增强阿苯达唑的杀虫活性，成为一种对抗幼虫棘球蚴病的化疗有用的化合物。
