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作为兽用抗寄生虫药的苯甲酰基苯基脲类。重点论述疗效、用法及耐药性的综述与展望。

Benzoylphenyl ureas as veterinary antiparasitics. An overview and outlook with emphasis on efficacy, usage and resistance.

作者信息

Junquera Pablo, Hosking Barry, Gameiro Marta, Macdonald Alicia

机构信息

Vetparcs GmbH, Zürich 8044, Switzerland.

Elanco Australasia Pty. Limited, Kemps Creek, 2178 NSW, Australia.

出版信息

Parasite. 2019;26:26. doi: 10.1051/parasite/2019026. Epub 2019 May 1.

DOI:10.1051/parasite/2019026
PMID:31041897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6492539/
Abstract

Six benzoylphenyl ureas are currently used in formulations approved as veterinary medicines: diflubenzuron for fly control mainly on cattle, lice and blowfly strike control on sheep, and lice control on farmed salmonids; lufenuron for flea control on dogs and cats and for lice control on farmed salmonids; triflumuron for lice and blowfly strike control on sheep; fluazuron for tick control on cattle; teflubenzuron for lice control on farmed salmon; and novaluron for fly and tick control on cattle and for flea control on dogs. Resistance to diflubenzuron and triflumuron has already been reported for sheep body lice and blowflies, and to fluazuron in cattle ticks. These and other minor veterinary usages, as well as the current status of resistance, are reviewed and perspectives for future opportunities are discussed based on unexplored potentials and threats posed by future resistance development.

摘要

目前有六种苯甲酰基苯基脲类药物被用于获批的兽用制剂中

除虫脲主要用于控制牛身上的苍蝇，控制绵羊身上的虱子和蝇蛆病，以及控制养殖鲑鱼身上的虱子；虱螨脲用于控制犬猫身上的跳蚤以及养殖鲑鱼身上的虱子；氟虫脲用于控制绵羊身上的虱子和蝇蛆病；氟啶脲用于控制牛身上的蜱虫；伏虫隆用于控制养殖鲑鱼身上的虱子；以及双苯氟脲用于控制牛身上的苍蝇和蜱虫以及犬身上的跳蚤。已经有报道称绵羊体虱和家蝇对除虫脲和氟虫脲产生了抗性，牛蜱对氟啶脲产生了抗性。本文对这些以及其他一些次要的兽用用途，以及当前的抗性状况进行了综述，并基于未来抗性发展带来的未被探索的潜力和威胁，讨论了未来机会的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c3/6492539/5ca4a77fffc2/parasite-26-26-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c3/6492539/db905ad8dbb2/parasite-26-26-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c3/6492539/4d5fad6e89a8/parasite-26-26-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c3/6492539/cb6bf602a0a0/parasite-26-26-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c3/6492539/bf288bfd26e1/parasite-26-26-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c3/6492539/5062020420a5/parasite-26-26-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c3/6492539/5ca4a77fffc2/parasite-26-26-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c3/6492539/db905ad8dbb2/parasite-26-26-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c3/6492539/4d5fad6e89a8/parasite-26-26-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c3/6492539/cb6bf602a0a0/parasite-26-26-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c3/6492539/bf288bfd26e1/parasite-26-26-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c3/6492539/5062020420a5/parasite-26-26-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c3/6492539/5ca4a77fffc2/parasite-26-26-fig6.jpg

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