挪威正常人群血清肌酸激酶（CK）水平的变化及持续高 CK 血症的发生率。特罗姆瑟研究。

Variation of serum creatine kinase (CK) levels and prevalence of persistent hyperCKemia in a Norwegian normal population. The Tromsø Study.

机构信息

Department of Neurology and Neurophysiology, University Hospital of North Norway, Tromsø N-9038, Norway.

出版信息

Neuromuscul Disord. 2011 Jul;21(7):494-500. doi: 10.1016/j.nmd.2011.04.007. Epub 2011 May 17.

DOI:10.1016/j.nmd.2011.04.007

Abstract

In this cross-sectional study we assessed the prevalence of hyperCKemia, defined as persistent CK values ≥210 U/L in women, ≥400 U/L in men <50 years and ≥280 U/L in men ≥50 years (reference values according to the Nordic Reference Interval Project). Blood samples were obtained from 12,828 participants in the 6th survey of The Tromsø Study. We identified 686 (5.3%) individuals with incidentally elevated CK. After a standardized control test, 169 persons (1.3%) had persistent hyperCKemia, i.e. 69.9% normalization. Use of statins or other causes of hyperCKemia were detected in 78 individuals (46.2%), giving a prevalence of "idiopathic hyperCKemia" of 0.71%. CK variation was highest in younger men and in females between 60 and 69 years. This study has identified persistent hyperCKemia in 1.3% of the normal population, and demonstrates the importance of performing controlled CK analyses, also in those with identified risk factors.

摘要

在这项横断面研究中，我们评估了高肌酸激酶血症的患病率，定义为女性持续肌酸激酶值≥210 U/L，男性<50 岁时≥400 U/L，男性≥50 岁时≥280 U/L（根据北欧参考区间项目的参考值）。从特罗姆瑟研究第六次调查的 12828 名参与者中采集了血液样本。我们发现 686 名（5.3%）个体的肌酸激酶意外升高。经过标准化的对照测试，169 人（1.3%）存在持续性高肌酸激酶血症，即 69.9%的正常化。在 78 名个体（46.2%）中检测到他汀类药物或其他引起高肌酸激酶血症的原因，从而得出“特发性高肌酸激酶血症”的患病率为 0.71%。肌酸激酶的变化在年轻男性和 60 至 69 岁的女性中最高。这项研究确定了正常人群中 1.3%存在持续性高肌酸激酶血症，并表明进行受控肌酸激酶分析的重要性，即使在已确定的危险因素患者中也是如此。