Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway.
Department of Neurology, University Hospital of North Norway, Tromsø, Norway.
Scand J Med Sci Sports. 2020 Dec;30(12):2437-2444. doi: 10.1111/sms.13809. Epub 2020 Sep 18.
Creatine kinase (CK) is an enzyme catalyzing energy reaction in muscle cells and has proven to modify cardiovascular risks. The influence of skeletal muscle activity on CK concentrations is a potential study confounder but is mainly reported in connection with sport activities. This study investigated the association between leisure physical exercise and CK and estimated the effect of physical exercise on the CK values. CK and leisure physical exercise defined as intensity, frequency, and duration subsets were measured in the population-based Tromsø study. Comparisons of CK at different exercise levels, multivariate analyses, and relative differences in CK between "never exercise" and "heavy exercise" (moderate or hard exercise ≥2 hours per week) subgroups were analyzed age- and sex-stratified in 12 796 men and women. CK increased significantly with higher levels of physical exercise intensity and frequency in both sexes analyzed by ANOVA. In a multivariate analysis, CK was independently associated with heavy exercise after adjusting for age, BMI, and blood pressure; OR 9.38 (95% CI 5.32-16.53), P < .0001 in men and OR 5.20 (95% CI 2.53-10.69), P < .0001 in women. The differences in CK between physically inactive and participants performing heavy exercise varied between 3.1% (women) and 6.4% (men) and was also larger in participants ≥50 years. In conclusion, CK was positively and independently associated with increasing leisure physical exercise in a general population. CK values associated with exercise were approximately twice as high in men than women, but exercise altered CK only modestly.
肌酸激酶（CK）是一种在肌肉细胞中催化能量反应的酶，已被证明可改变心血管风险。骨骼肌活动对 CK 浓度的影响是一个潜在的研究混杂因素，但主要与运动活动有关。本研究调查了休闲体育锻炼与 CK 之间的关系，并估计了体育锻炼对 CK 值的影响。在基于人群的特罗姆瑟研究中，测量了 CK 和休闲体育锻炼（定义为强度、频率和持续时间子集）。在年龄和性别分层的 12796 名男性和女性中，比较了不同运动水平的 CK、多元分析以及“从不运动”和“剧烈运动”（中度或剧烈运动≥每周 2 小时）亚组之间 CK 的相对差异。通过 ANOVA 分析，在男女两性中，CK 随体育锻炼强度和频率的增加而显著增加。在多变量分析中，在调整年龄、BMI 和血压后，CK 与剧烈运动独立相关；男性的 OR 为 9.38（95%CI 5.32-16.53），P<0.0001，女性的 OR 为 5.20（95%CI 2.53-10.69），P<0.0001。在不活跃的参与者和进行剧烈运动的参与者之间，CK 的差异在 3.1%（女性）和 6.4%（男性）之间，在年龄≥50 岁的参与者中差异更大。总之，在一般人群中，CK 与休闲体育锻炼的增加呈正相关且独立相关。与运动相关的 CK 值在男性中约为女性的两倍，但运动对 CK 的改变幅度较小。
