Department of Biochemistry, La Trobe University, Victoria, Australia.
Trends Parasitol. 2011 Aug;27(8):330-4. doi: 10.1016/j.pt.2011.04.003. Epub 2011 May 17.
New technologies and some disillusionment with subunit vaccines has led to increased interest in the development of whole parasite vaccines for malaria. Instead, the current priority should be to build on the partial success of the recombinant protein sporozoite vaccine, RTS,S. There are many possible options for delivering a subunit vaccine but the simplest option, formulating recombinant proteins in an adjuvant, should be fully explored. Numerous options exist for inducing heightened immune responses and for tackling the problem of diversity, but development of recombinant protein subunit vaccines requires a more detailed knowledge of the conformation of the leading vaccine candidates.
新技术和对亚单位疫苗的一些幻想破灭，导致人们对疟疾全寄生虫疫苗的开发产生了浓厚的兴趣。相反，目前的重点应该是在重组蛋白子孢子疫苗 RTS,S 的部分成功的基础上继续努力。有许多可能的选择可以用于输送亚单位疫苗，但最简单的选择，即将重组蛋白在佐剂中进行配方，应该得到充分的探索。有许多选择可以用来诱导更高的免疫反应和解决多样性的问题，但重组蛋白亚单位疫苗的开发需要更详细地了解主要候选疫苗的构象。
