间充质干细胞在未来疫苗合成中的应用。

The Application of Mesenchymal Stem Cells in Future Vaccine Synthesis.

作者信息

Zhang Rui, Duan Xingxiang, Liu Ye, Xu Jia, Al-Bashari Abdullkhaleg Ali Ghaleb, Ye Peng, Ye Qingsong, He Yan

机构信息

Center of Regenerative Medicine & Department of Stomatology, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Australian Rivers Institute and School of Environment and Science, Griffith University, Nathan, QLD 4111, Australia.

出版信息

Vaccines (Basel). 2023 Oct 24;11(11):1631. doi: 10.3390/vaccines11111631.

DOI:10.3390/vaccines11111631

PMID:38005963

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10675160/

Abstract

Vaccines have significant potential in treating and/or preventing diseases, yet there remain challenges in developing effective vaccines against some diseases, such as AIDS and certain tumors. Mesenchymal stem cells (MSCs), a subset of cells with low immunogenicity, high proliferation potential, and an abundant source of extracellular vesicles (EVs), represent one of the novel and promising vaccine platforms. This review describes the unique features and potential mechanisms of MSCs as a novel vaccine platform. We also cover aspects such as the safety and stability of MSCs that warrant future in-depth studies.

摘要

疫苗在治疗和/或预防疾病方面具有巨大潜力，但在开发针对某些疾病（如艾滋病和某些肿瘤）的有效疫苗方面仍存在挑战。间充质干细胞（MSCs）是一类免疫原性低、增殖潜力高且细胞外囊泡（EVs）来源丰富的细胞亚群，是新型且有前景的疫苗平台之一。本综述描述了间充质干细胞作为新型疫苗平台的独特特征和潜在机制。我们还涵盖了间充质干细胞的安全性和稳定性等方面，这些方面值得未来深入研究。