CCL3L1 和 CCR5 变异对哥伦比亚西北部人群结核病的影响。
Influence of variations in CCL3L1 and CCR5 on tuberculosis in a northwestern Colombian population.
机构信息
The Veterans Administration Center for AIDS and HIV-1 infection and Center for Personalized Medicine, South Texas Veterans Health Care System and Department of Medicine, University of Texas Health Science Center, San Antonio, USA.
出版信息
J Infect Dis. 2011 Jun 1;203(11):1590-4. doi: 10.1093/infdis/jir145.
Abstract
We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the pro-inflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS.
摘要
我们调查了 CCR5 多态性（主要的人类免疫缺陷病毒 [HIV]-1 核心受体）及其有效配体 CCL3L1 的拷贝数与来自哥伦比亚的 298 个人的结核病之间的关联。CCR5-HHD 单倍型是 HIV-AIDS 易感性增加的已知遗传决定因素，CCL3L1 的高拷贝数是 CCL3/CCL3L1 趋化因子表达增强的已知遗传决定因素，这两者都与结核病的存在有关。此外，CCR5-HHD 与 CCR5 基因和表面表达的增加有关。这些结果证实了 CCR5 及其配体的促炎作用与活动性结核病之间的紧密联系，并表明趋化因子-趋化因子受体遗传决定因素除了 HIV/AIDS 之外，还可能影响结核病。
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