Department of Tuberculosis, Hangzhou Red Cross Hospital, Hangzhou, China.
Innate Immun. 2020 Jul;26(5):358-363. doi: 10.1177/1753425919891662. Epub 2019 Dec 25.
A meta-analysis was carried out in this study by summarizing relevant research to evaluate the relationship between rs2107538 polymorphism in the chemotactic chemokine ligand 5 (CCL5) gene and tuberculosis (TB) susceptibility. Published studies were retrieved from PubMed, Embase, and CNKI databases using the keywords 'CCL5', 'TB', and 'polymorphism'. Nine studies involving 2584 patients with TB and 2265 controls were included in the current meta-analysis. The combined results suggested that the rs2107538 polymorphism was correlated with TB susceptibility (recessive model: OR = 1.45, 95% CI = 1.02-2.07). Subgroup analysis according to race indicated that such correlation could be detected in Caucasians (CT versus CC: OR = 1.53, 95% CI = 1.20-1.95; dominant model: OR = 1.58, 95% CI = 1.25-1.99), but not in East Asian, South Asian, and South African populations. In conclusion, the results of our meta-analysis suggest that rs2107538 polymorphism might contribute to the risk of TB, especially in Caucasians. Well-designed studies with more subjects will be required for further validation of these results.
本研究通过汇总相关研究进行了荟萃分析，以评估趋化因子配体 5（CCL5）基因 rs2107538 多态性与结核病（TB）易感性之间的关系。使用关键词“CCL5”、“TB”和“多态性”从 PubMed、Embase 和中国知网（CNKI）数据库中检索到已发表的研究。当前的荟萃分析纳入了 9 项涉及 2584 例 TB 患者和 2265 例对照的研究。合并结果表明，rs2107538 多态性与 TB 易感性相关（隐性模型：OR=1.45，95%CI=1.02-2.07）。根据种族进行的亚组分析表明，这种相关性可以在高加索人群中检测到（CT 与 CC：OR=1.53，95%CI=1.20-1.95；显性模型：OR=1.58，95%CI=1.25-1.99），但在东亚、南亚和南非人群中则不能。总之，本荟萃分析的结果表明，rs2107538 多态性可能与 TB 的风险相关，尤其是在高加索人群中。需要更多对象的设计良好的研究来进一步验证这些结果。
