Department of Medical and Surgical Sciences and Biotechnologies, La Sapienza University of Rome, Latina, Italy.
Minerva Med. 2011 Jun;102(3):177-86.
Adequate postoperative analgesia is a prerequisite for successful ambulatory surgery and continues to be a challenge for anesthesiologists. The goal of the study was to analyze what are determinants of patients' overall satisfaction in postoperative pain management after ambulatory hand surgery.
Patients undergoing ambulatory hand surgery received oral fixed association tramadol/acetaminophen 37.5/325 mg every 6 hours during the first 48 hours after operation. Analgesic efficacy was evaluated by self-assessment of pain intensity by numeric rating scale. Patients also recorded total number of daily study analgesic tablets, frequency and severity of adverse events, sleep pain interference (SPI 0-10), number of rescue doses and patient global assessment (PGA) on a 4-grade scale. Success ratings on the PGA were considered "good" and "excellent". Preoperative pain intensity, analgesic use, and expectation were also recorded.
One hundred and forty-three subjects were evaluated in the study. The percentage of patients who reported rating of success on the PGA was 88.8%. The most significant determinant of failure on the PGA was the presence of moderate to severe adverse events (R=-0.85). Determinants of ratings of success on PGA were adequate analgesia and SPI ≤ 4. Predictors of successful patient satisfaction were preoperative pain ≤ 4 on NRS, lack of preoperative analgesic consumption, expected pain >6 on NRS, and lower education level. Weak correlation (R=0.26) was observed between mean daily pain intensity and analgesics intake.
Results indicate that the oral association tramadol/acetaminophen 37,5/325 mg is effective for the management of postoperative pain after ambulatory hand surgery. The lack of adverse events is the most important determinant of patient satisfaction, followed by the analgesic efficacy.
充分的术后镇痛是门诊手术成功的前提,这对麻醉医生来说仍然是一个挑战。本研究的目的是分析影响门诊手部手术后患者对整体术后疼痛管理满意度的因素。
接受门诊手部手术的患者在术后的前 48 小时内,每 6 小时口服固定剂量的曲马多/对乙酰氨基酚 37.5/325mg。通过数字评分量表评估患者的镇痛效果。患者还记录了每日研究镇痛片的总数、不良反应的频率和严重程度、睡眠疼痛干扰(SPI 0-10)、解救剂量的次数和患者的整体评估(PGA)。PGA 的成功评分被认为是“好”和“优秀”。还记录了术前疼痛强度、镇痛药物使用和预期。
本研究共评估了 143 例患者。报告 PGA 评分成功的患者比例为 88.8%。PGA 评分失败的最显著决定因素是存在中度至重度不良反应(R=-0.85)。PGA 评分成功的决定因素是充分的镇痛和 SPI≤4。预测患者满意度的成功因素是术前 NRS 疼痛评分≤4、术前无镇痛药物使用、预期 NRS 疼痛评分>6 和较低的教育水平。平均每日疼痛强度和镇痛药用量之间存在弱相关(R=0.26)。
结果表明,曲马多/对乙酰氨基酚 37.5/325mg 口服联合用药对门诊手部手术后的疼痛管理有效。无不良反应是患者满意度的最重要决定因素,其次是镇痛效果。