Institute and Intelligent of Machines, Chinese Academy of Sciences, Hefei, Anhui, PR China.
Hypertens Res. 2011 Jul;34(7):884-7. doi: 10.1038/hr.2011.41. Epub 2011 May 19.
Aortic pulse wave velocity, calculated from pulse transit time (PTT), is often used as an indicator of arterial stiffness and suggested to be standardized for heart rate (HR). This study aimed to determine whether PTT obtained directly from radial arterial waveforms could be used to assess arterial stiffness and the effect of HR on it. Measurements of anthropometric parameters, blood pressure (BP) and radial PTT were taken in 266 apparently healthy adults (113 men and 153 women; age 18-78 years). BP and radial PTT were measured in a subgroup of 11 young subjects (seven men and four women, age 24-35 years) in a 3-month follow-up study, which aimed to investigate the effect of HR changes. Radial PTT was significantly higher in men compared with women (0.116 ± 0.022 s compared with 0.103 ± 0.031 s, P < 0.001). It was inversely related to age in men and women (r=-0.838 and r=-0.804, respectively, P < 0.01 for both). Multiple regression analysis showed that HR was a potent predictor of radial PTT in addition to age, sex and systolic BP. There was no significant change in radial PTT when HR ranged from 60 to 75 b.p.m. A significant decrease was found in radial PTT when HR was up to 80 b.p.m. (P < 0.01). These findings indicate that the simple and easily obtainable radial PTT could be a useful index of arterial stiffness, and HR changes should be considered when it is up to 80 b.p.m.
脉搏波传导速度（Pulse Wave Velocity，PWV）可通过脉搏波传导时间（Pulse Transit Time，PTT）计算得出，通常被用作动脉僵硬度的指标，并建议对其进行心率（Heart Rate，HR）标准化。本研究旨在确定是否可以直接从桡动脉波形中获得 PTT，以评估动脉僵硬度以及 HR 对其的影响。在 266 名健康成年人（男性 113 名，女性 153 名；年龄 18-78 岁）中测量了人体测量参数、血压（Blood Pressure，BP）和桡动脉 PTT。在一项为期 3 个月的随访研究中，对 11 名年轻受试者（男性 7 名，女性 4 名，年龄 24-35 岁）进行了血压和桡动脉 PTT 的测量，旨在研究 HR 变化的影响。男性的桡动脉 PTT 明显高于女性（0.116±0.022s 比 0.103±0.031s，P＜0.001）。男性和女性的桡动脉 PTT 均与年龄呈负相关（r=-0.838 和 r=-0.804，均 P＜0.01）。多元回归分析显示，除了年龄、性别和收缩压外，HR 也是桡动脉 PTT 的一个有力预测因素。当 HR 在 60-75 次/分时，桡动脉 PTT 没有明显变化。当 HR 达到 80 次/分时，桡动脉 PTT 显著降低（P＜0.01）。这些发现表明，简单且易于获得的桡动脉 PTT 可能是动脉僵硬度的有用指标，当 HR 达到 80 次/分时，应考虑 HR 变化。
