Postgraduate Studies Program in Cardiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
J Hum Hypertens. 2012 Jun;26(6):374-80. doi: 10.1038/jhh.2011.48. Epub 2011 May 19.
Patients with hypertension usually report lower health-related quality of life (HRQoL), but it is unclear whether this is secondary to high blood pressure (BP) per se, drug treatment or awareness of disease. In a cross-sectional study using a multistage population-based sample, participants were interviewed and examined at home. Hypertension was defined by BP ≥140/90 mm Hg or use of BP-lowering drugs. HRQoL was assessed through the Short-Form Health Survey (SF-12) and presented as the physical component summary (PCS), mental component summary (MCS) and the SF-12 eight-domain scale. In total, 1858 individuals were evaluated, being 60.1% women, aged 52.5 ± 4.1 years old, and 39.9% men, aged 47.2 ± 9.1 years old. Prevalence of hypertension was 34.2% (95% CI 31.5-36.9). The PCS scores for hypertensive and normotensive participants were 49.4 (CI 48.6-50.2) and 51.06 (CI 50.4-51.7) (P=0.01), respectively, and the MCS scores were 49.1 (CI 47.9-50.3) and 50.5 (CI 49.6-51.2) (P=0.06), respectively. Participants with hypertension and not using BP drugs had higher HRQoL scores (PCS 49.6; MCS 51.9) than those using BP drugs either with uncontrolled (PCS 45.3; MCS 49.4) or controlled BP (PCS 46.2; MCS 47.7; P<0.05). We concluded that individuals with hypertension have worse quality of life, particularly when their BP is controlled by drugs. This perception may lead to lower rates of adherence to treatment.
高血压患者通常报告的健康相关生活质量（HRQoL）较低，但尚不清楚这是血压（BP）本身、药物治疗还是对疾病的认识所致。本研究采用多阶段基于人群的样本进行横断面研究，在家中对参与者进行访谈和检查。高血压定义为 BP≥140/90mmHg 或使用降压药物。HRQoL 通过健康调查简表（SF-12）评估，并以生理成分综合评分（PCS）、心理成分综合评分（MCS）和 SF-12 八个维度量表呈现。共评估了 1858 人，其中 60.1%为女性，年龄为 52.5±4.1 岁，39.9%为男性，年龄为 47.2±9.1 岁。高血压患病率为 34.2%（95%CI 31.5-36.9）。高血压和血压正常参与者的 PCS 评分分别为 49.4（CI 48.6-50.2）和 51.06（CI 50.4-51.7）（P=0.01），MCS 评分分别为 49.1（CI 47.9-50.3）和 50.5（CI 49.6-51.2）（P=0.06）。未使用降压药物的高血压患者的 HRQoL 评分更高（PCS 49.6；MCS 51.9），而使用降压药物但 BP 未得到控制（PCS 45.3；MCS 49.4）或得到控制（PCS 46.2；MCS 47.7）的患者 HRQoL 评分较低（P<0.05）。我们的结论是，高血压患者的生活质量较差，尤其是当他们的 BP 通过药物控制时。这种认知可能会导致治疗的依从性降低。
