Chiang Chih-Kang, Peng Yu-Sen, Chiang Shou-Shan, Yang Chwei-Shiun, He Yang-Hsun, Hung Kuan-Yu, Wu Kwan-Dun, Wu Ming-Shiou, Fang Cheng-Chung, Tsai Tun-Jun, Chen Wang-Yu
Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
Blood Purif. 2004;22(6):490-8. doi: 10.1159/000081730. Epub 2004 Oct 27.
BACKGROUND/AIMS: Health-related quality of life (HRQOL) is an important determinant of treatment effectiveness in dialysis patients. To our knowledge, there are no reports evaluating HRQOL of hemodialysis (HD) in Chinese patients. The purpose of this study is to present our results about HRQOL using the 36-Item Short-Form (SF-36) questionnaire on Taiwanese hemodialysis patients.
HRQOL was measured by using the SF-36 questionnaire in 497 HD patients in five hospitals.
The following attributes, male gender, age <50 years old, higher education level (HEL), marriage status, employment status (EPS), less comorbid medical condition (CMC), and non-diabetic patients (NDP) were all predicted on a better Physical Component Scale (PCS). Age <50 years old, body mass index >18.5, HEL, EPS and NDP were all predicted on a higher Mental Component Scale (MCS). Scales contributing to a summary measure of physical health, the PCS score was significantly lower in women (35.0 +/- 12.3) than in men (37.9 +/- 12.3). However, there was no difference in the MCS score between women and men. In multivariate analysis, age, CMC, diabetes, serum creatinine (SCr), and erythropoietin responsiveness were significant independent predictors of PCS. Diabetes, educational level, SCr, and erythropoietin responsiveness were significant independent predictors of MCS. All of the individual scales were lower in Taiwanese HD patients than in both the general Taiwanese and US population. Each of the individual scales and MCS scores were substantially lower in the Taiwan HD group than in the US HD cohort. However, the bodily pain of PCS was significantly higher in the Taiwan HD group, although the mean PCS scores for the Taiwan HD group and the US HD study participants were nearly equal at 36.3 and 36.1, respectively.
The physical and mental aspects of quality of life are substantially lower for Taiwanese HD patients, except for higher bodily pain tolerance. A number of demographic and clinical characteristics have a significant impact on HRQOL in Taiwanese HD patients.
背景/目的：健康相关生活质量（HRQOL）是透析患者治疗效果的重要决定因素。据我们所知，尚无关于中国患者血液透析（HD）的HRQOL评估报告。本研究的目的是使用36项简短形式（SF - 36）问卷呈现我们关于台湾血液透析患者HRQOL的结果。
使用SF - 36问卷对五家医院的497例HD患者进行HRQOL测量。
以下特征，男性、年龄<50岁、高等教育水平（HEL）、婚姻状况、就业状况（EPS）、较少的合并症（CMC）以及非糖尿病患者（NDP），均预示着更好的身体成分量表（PCS）。年龄<50岁、体重指数>18.5、HEL、EPS和NDP均预示着更高的心理成分量表（MCS）。对身体健康综合测量有贡献的量表中，女性的PCS得分（35.0±12.3）显著低于男性（37.9±12.3）。然而，女性和男性的MCS得分没有差异。在多变量分析中，年龄、CMC、糖尿病、血清肌酐（SCr）和促红细胞生成素反应性是PCS的显著独立预测因素。糖尿病、教育水平、SCr和促红细胞生成素反应性是MCS的显著独立预测因素。台湾HD患者的所有单项量表得分均低于台湾普通人群和美国人群。台湾HD组的每个单项量表和MCS得分均显著低于美国HD队列。然而，台湾HD组的PCS身体疼痛得分显著更高，尽管台湾HD组和美国HD研究参与者的PCS平均得分分别为36.3和36.1，几乎相等。
台湾HD患者的生活质量在身体和心理方面显著较低，但身体疼痛耐受性较高。一些人口统计学和临床特征对台湾HD患者的HRQOL有显著影响。
