癌症转移至骨骼：致命吸引力。
Cancer to bone: a fatal attraction.
机构信息
Department of Medicine, Division of Molecular Oncology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
出版信息
Nat Rev Cancer. 2011 Jun;11(6):411-25. doi: 10.1038/nrc3055. Epub 2011 May 19.
Abstract
When cancer metastasizes to bone, considerable pain and deregulated bone remodelling occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and sculpt the bone microenvironment to enhance tumour growth and to promote bone invasion. Understanding the crucial components of the bone microenvironment that influence tumour localization, along with the tumour-derived factors that modulate cellular and protein matrix components of bone to favour tumour expansion and invasion, is central to the pathophysiology of bone metastases. Basic findings of tumour-bone interactions have uncovered numerous therapeutic opportunities that focus on the bone microenvironment to prevent and treat bone metastases.
摘要
当癌症转移到骨骼时，会发生严重的疼痛和骨骼代谢紊乱，极大地降低了治愈的可能性。转移的肿瘤细胞会动员和塑造骨骼微环境，以促进肿瘤生长和促进骨骼侵袭。了解影响肿瘤定位的骨骼微环境的关键组成部分，以及调节骨骼细胞和蛋白质基质成分以促进肿瘤扩张和侵袭的肿瘤衍生因子，是骨骼转移的病理生理学的核心。肿瘤-骨骼相互作用的基础发现揭示了许多治疗机会，这些机会集中在骨骼微环境上，以预防和治疗骨骼转移。
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