矿物粉尘对肺泡巨噬细胞过氧化氢和超氧阴离子释放的抑制作用：与锑、铅和砷含量的相关性。

Depression of alveolar macrophage hydrogen peroxide and superoxide anion release by mineral dusts: correlation with antimony, lead, and arsenic contents.

作者信息

Gulyas H, Labedzka M, Gercken G

机构信息

Department of Biochemistry, University of Hamburg, Federal Republic of Germany.

出版信息

Environ Res. 1990 Apr;51(2):218-29. doi: 10.1016/s0013-9351(05)80091-x.

DOI:10.1016/s0013-9351(05)80091-x

PMID:2159400

Abstract

Activated rabbit alveolar macrophages were incubated with airborne dusts from four West German sites (1 to 200 micrograms/10(6) cells) and waste incinerator fly ash fractions (50 to 500 micrograms/10(6) cells). Quartz dust DQ 12 (5 to 200 micrograms/10(6) cells) and Fe2O3 (0.05 to 50 micrograms/10(6) cells) were used as control dusts. The zymosan-stimulated hydrogen peroxide and superoxide anion release of the macrophages were not affected significantly by Fe2O3. All other investigated dusts decreased the two cell functions which were correlated negatively with surfaces, particle numbers, and antimony, lead, and arsenic contents of the dusts. The influence of heavy metal antagonisms and dust surfaces on dust toxicity against alveolar macrophages is discussed.

摘要

将活化的兔肺泡巨噬细胞与来自四个西德地点的空气传播粉尘（1至200微克/10⁶个细胞）以及垃圾焚烧炉飞灰级分（50至500微克/10⁶个细胞）一起孵育。石英粉尘DQ 12（5至200微克/10⁶个细胞）和Fe₂O₃（0.05至50微克/10⁶个细胞）用作对照粉尘。Fe₂O₃对酵母聚糖刺激的巨噬细胞过氧化氢和超氧阴离子释放没有显著影响。所有其他研究的粉尘均降低了这两种细胞功能，这两种细胞功能与粉尘的表面积、颗粒数量以及锑、铅和砷含量呈负相关。讨论了重金属拮抗作用和粉尘表面对粉尘对肺泡巨噬细胞毒性的影响。