Thoraxcenter, Erasmus MC, Ba583, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.
Int J Cardiovasc Imaging. 2012 Apr;28(4):695-703. doi: 10.1007/s10554-011-9882-6. Epub 2011 May 19.
We explored the impact of patient demographics, anthropometric measurements, cardiovascular risk factors, and soluble biomarkers on necrotic core and atheroma size in patients with coronary disease. The IBIS-2 trial enrolled 330 patients. In the multivariate analysis, at baseline, creatinine had a positive, whereas baseline mean lumen diameter and myeloperoxidase had a negative, independent association with percentage of necrotic core (PNC); while age, glomerular filtration rate <60, HbA1c, previous PCI or CABG and baseline % diameter stenosis were positively, and acute coronary syndromes (ACS) were negatively associated with baseline percentage atheroma volume (PAV). The variables associated with a decrease in PNC from baseline were darapladib, ACS and a large content of NC at baseline, while variables associated with an increase in PNC were previous stroke and % diameter stenosis at baseline. Those variables associated with a decrease in PAV from baseline were waist circumference, statin use, CD40L and baseline PAV, while the only variable associated with an increase in PAV was baseline diastolic blood pressure. Treatment with darapladib was associated with a decrease in necrotic core, but was not associated with a decrease in percentage atheroma volume. On the contrary, statin use was only associated with a decrease in percentage atheroma volume.
我们探讨了患者人口统计学、人体测量学测量、心血管危险因素和可溶性生物标志物对冠心病患者坏死核心和动脉粥样硬化斑块大小的影响。IBIS-2 试验纳入了 330 名患者。在多变量分析中，基线时肌酐呈正相关，而基线平均管腔直径和髓过氧化物酶呈负相关，与坏死核心百分比（PNC）独立相关；而年龄、肾小球滤过率<60、HbA1c、既往 PCI 或 CABG 和基线%直径狭窄呈正相关，急性冠脉综合征（ACS）与基线动脉粥样硬化斑块体积百分比（PAV）呈负相关。与 PNC 从基线下降相关的变量是达拉普利，ACS 和基线 NC 含量高，而与 PNC 增加相关的变量是既往卒中和基线%直径狭窄。与 PAV 从基线下降相关的变量是腰围、他汀类药物使用、CD40L 和基线 PAV，而与 PAV 增加相关的唯一变量是基线舒张压。达拉普利治疗与坏死核心减少相关，但与动脉粥样硬化斑块体积百分比减少无关。相反，他汀类药物治疗仅与动脉粥样硬化斑块体积百分比减少相关。
