斑马鱼的视觉系统及其在人类眼部疾病模型中的应用。
The visual system of zebrafish and its use to model human ocular diseases.
机构信息
Department of Cell and Developmental Biology, University College, London,UK.
出版信息
Dev Neurobiol. 2012 Mar;72(3):302-27. doi: 10.1002/dneu.20919.
Abstract
Free swimming zebrafish larvae depend mainly on their sense of vision to evade predation and to catch prey. Hence, there is strong selective pressure on the fast maturation of visual function and indeed the visual system already supports a number of visually driven behaviors in the newly hatched larvae.The ability to exploit the genetic and embryonic accessibility of the zebrafish in combination with a behavioral assessment of visual system function has made the zebrafish a popular model to study vision and its diseases.Here, we review the anatomy, physiology, and development of the zebrafish eye as the basis to relate the contributions of the zebrafish to our understanding of human ocular diseases.
摘要
自由游动的斑马鱼幼鱼主要依靠视觉来逃避捕食和捕食猎物。因此，视觉功能的快速成熟受到强烈的选择压力，事实上，视觉系统已经在刚孵化的幼鱼中支持了一些视觉驱动的行为。利用斑马鱼的遗传和胚胎可及性，并结合视觉系统功能的行为评估，使斑马鱼成为研究视觉及其疾病的热门模型。在这里，我们回顾了斑马鱼眼睛的解剖结构、生理学和发育，作为将斑马鱼对人类眼部疾病的认识的基础。
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