葡萄膜炎相关杀伤免疫球蛋白样受体基因
Killer immunoglobulin-like receptor genes in uveitis.
机构信息
Ocular Inflammatory Disease Center, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California 90095, USA.
出版信息
Ocul Immunol Inflamm. 2011 Jun;19(3):192-201. doi: 10.3109/09273948.2010.538798.
PURPOSE
to review the function and genetics of killer immunoglobulin-like receptors (KIRs) and studies of KIR genetic associations with uveitis.
METHODS
Review of published studies.
RESULTS
KIRs are receptors on NK and some T cells. They may inhibit or activate cellular function, such as cytotoxicity and cytokine production. Studies have been published examining KIR gene associations with birdshot chorioretinopathy (BCR), Vogt-Koyanagi-Harada (VKH) disease, and HLA-B27-associated acute anterior uveitis (AAU) and axial spondyloarthropathy. Evidence for increased activating and/or less inhibitory KIR and HLA gene combinations was found for BCR and VKH disease. In HLA-B27-associated disease, a trend toward decreased activation and stronger inhibition was found, except for the weakly inhibitory 3DL1 and Bw4(T80) combination. This latter combination was also found to confer risk in BCR.
CONCLUSIONS
KIR genetics are complex, as are the functions of KIR-bearing cells. Nonetheless, evidence for KIRs in the pathogenesis of uveitis has been found.
目的
综述杀伤细胞免疫球蛋白样受体（KIR）的功能和遗传学，以及 KIR 遗传关联与葡萄膜炎的研究进展。
方法
对已发表的研究进行综述。
结果
KIR 是自然杀伤（NK）细胞和部分 T 细胞表面的受体。它们可能抑制或激活细胞功能，如细胞毒性和细胞因子产生。已有研究探讨了 KIR 基因与鸟枪弹样脉络膜视网膜病变（BCR）、Vogt-小柳原田病（VKH）和 HLA-B27 相关的急性前葡萄膜炎（AAU）和中轴型脊柱关节炎的关联。研究发现，在 BCR 和 VKH 疾病中，与增加的激活和/或减少的抑制性 KIR 和 HLA 基因组合相关。在 HLA-B27 相关疾病中，除了弱抑制性的 3DL1 和 Bw4（T80）组合外，发现存在向激活减少和抑制增强的趋势。该后一组合也被发现与 BCR 相关的风险有关。
结论
KIR 遗传学复杂，具有 KIR 受体的细胞的功能也很复杂。尽管如此，已经发现 KIR 在葡萄膜炎发病机制中的作用。
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