Wakefield D, Buckley R, Golding J, McCluskey P, Abi-Hanna D, Charlesworth J, Pussell B
Laboratory of Ocular Immunology, School of Pathology, University of New South Wales, Australia.
Hum Immunol. 1988 Apr;21(4):233-7. doi: 10.1016/0198-8859(88)90032-8.
We have studied allotypes of the fourth component of complement (C4) in 44 patients with inflammatory eye disease in order to define genetic susceptibility factors further. Twenty-six patients had uveitis (18 had anterior uveitis) and 18 patients had retinal vasculitis. There was an increased incidence of the C4B2 allotype in patients with anterior uveitis (pc less than 0.002), especially in HLA B27 positive males. In contrast, there was no increased incidence of specific allotypes in patients with posterior uveitis or retinal vasculitis. This genetic association may form part of a disease susceptibility supratype in patients with anterior uveitis.
为了进一步确定遗传易感性因素，我们研究了44例炎性眼病患者的补体第四成分（C4）的同种异型。26例患者患有葡萄膜炎（18例为前葡萄膜炎），18例患者患有视网膜血管炎。前葡萄膜炎患者中C4B2同种异型的发生率增加（P<0.002），尤其是在HLA B27阳性男性中。相比之下，后葡萄膜炎或视网膜血管炎患者中特定同种异型的发生率没有增加。这种遗传关联可能是前葡萄膜炎患者疾病易感性超型的一部分。
