玻璃体内膦甲酸治疗水痘带状疱疹病毒引起的阿昔洛韦耐药性急性视网膜坏死。
Intravitreal foscarnet for the treatment of acyclovir-resistant acute retinal necrosis caused by varicella zoster virus.
机构信息
Department of Ophthalmology, Seoul St. Mary's Hospital,College of Medicine, The Catholic University of Korea, Seoul, Korea.
出版信息
Ocul Immunol Inflamm. 2011 Jun;19(3):212-3. doi: 10.3109/09273948.2010.544857.
PURPOSE
To report of a case of acute retinal necrosis (ARN), successfully treated with intravitreal foscarnet.
METHODS
Case report.
RESULTS
A 40-year-old man diagnosed with varicella zoster virus (VZV)-induced ARN failed standard acyclovir treatment. He was treated subsequently with intravenous foscarnet, but developed acute renal failure after 1 day of treatment. All systemic anti-viral agents were discontinued, and intravitreal foscarnet was administered weekly. After 5 injections, the retinitis was dramatically improved.
CONCLUSIONS
Intravitreal foscarnet was efficacious in the treatment of acyclovir-resistant ARN caused by VZV. It may be used as the sole treatment in patients with intolerance to systemic administration.
目的
报告一例成功用玻璃体内膦甲酸治疗的急性视网膜坏死（ARN）。
方法
病例报告。
结果
一名 40 岁男性，诊断为水痘带状疱疹病毒（VZV）诱导的 ARN，阿昔洛韦标准治疗失败。随后他接受了更昔洛韦静脉治疗，但在治疗 1 天后发生急性肾衰竭。所有全身抗病毒药物均被停用，每周行玻璃体内膦甲酸注射。5 次注射后，视网膜炎显著改善。
结论
玻璃体内膦甲酸对 VZV 引起的阿昔洛韦耐药性 ARN 治疗有效。对于不能耐受全身给药的患者，它可以作为唯一的治疗方法。
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