University of Messina, Department of Neuroscience , Psychiatric and Anesthesiological Sciences, Policlinico Universitario "G. Martino", Via C. Valeria, Messina , Italy.
Expert Opin Drug Saf. 2011 Nov;10(6):891-9. doi: 10.1517/14740338.2011.586627. Epub 2011 May 20.
Exposure to anesthetics in the health environment may entail a health risk for patients and operating room personnel. Knowing the effects of anesthetic agents on genetic material could be a valuable basic support for anesthesia care providers to improve treatment performance, increase patient safety and reduce the risks for patients and staff in the operating room.
Relevant literature was identified using MEDLINE, CINAHL® and Cochrane Library databases. Over 200 abstracts for articles published from 1980 to 2010 were examined. Original articles were reviewed and relevant citations from these articles were also considered.
Despite some conflicting results, the current available data indicate that exposure to anesthetics, especially nitrous oxide and halogenated agents, is associated with general and genotoxic risks, whereas intravenous agents, such as propofol and its metabolites are not associated with genotoxic effects. Moreover, given that different anesthetic drugs are used in combination it is, thus, very difficult to understand whether the observed effects or absence of effects are due to an individual agent action or linked to a synergy action of different anesthetics involved. Further clinical and experimental evidence is warranted.
在医疗环境中接触麻醉剂可能会对患者和手术室人员的健康造成风险。了解麻醉剂对遗传物质的影响可能为麻醉护理提供者提供有价值的基础支持，以改善治疗效果、提高患者安全性并降低手术室患者和工作人员的风险。
使用 MEDLINE、CINAHL® 和 Cochrane 图书馆数据库确定相关文献。检查了 1980 年至 2010 年发表的文章的 200 多篇摘要。审查了原始文章，并考虑了这些文章的相关引文。
尽管存在一些相互矛盾的结果，但目前可用的数据表明，接触麻醉剂，特别是一氧化二氮和卤代麻醉剂，与一般和遗传毒性风险有关，而静脉内麻醉剂，如丙泊酚及其代谢物则与遗传毒性作用无关。此外，由于不同的麻醉药物联合使用，因此很难理解观察到的效果或缺乏效果是由于单一药物作用还是与所涉及的不同麻醉剂的协同作用有关。需要进一步的临床和实验证据。
