[神经母细胞瘤细胞分化过程中环核苷酸细胞内浓度的变化]
[Changes in the intracellular concentration of cyclic nucleotides in the differentiation of neuroblastoma cells].
作者信息
Busse E, Kornhuber B
机构信息
J. W. Goethe-Universität, Kinderklinik, Frankfurt.
出版信息
Onkologie. 1990 Feb;13(1):12-6. doi: 10.1159/000216711.
PMID:2159608
Abstract
High performance liquid chromatography allows a simultaneous determination of ATP, CTP, GTP, and the cyclic nucleotides. During cell differentiation initiated by DBcAMP, we observed an increase in ATP, cAMP, GTP and an decrease in CTP, cCMP, and cGMP levels. It is being discussed the changes of relation between the triphosphates their corresponding cyclic nucleotides during the differentiation of NB cells.
摘要
高效液相色谱法可同时测定三磷酸腺苷（ATP）、三磷酸胞苷（CTP）、三磷酸鸟苷（GTP）和环核苷酸。在用二丁酰环磷腺苷（DBcAMP）启动细胞分化过程中，我们观察到ATP、环磷酸腺苷（cAMP）、GTP水平升高，而CTP、环磷酸胞苷（cCMP）和环磷酸鸟苷（cGMP）水平降低。目前正在讨论神经母细胞瘤（NB）细胞分化过程中三磷酸核苷酸与其相应环核苷酸之间关系的变化。
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