Jullien V
Université Paris Descartes, Inserm U 663, Service de Pharmacologie Clinique, Hôpital Saint-Vincent de Paul, 74-82, avenue Denfert-Rochereau, 75014 Paris, France.
Arch Pediatr. 2011 May;18 Suppl 1:S42-7. doi: 10.1016/S0929-693X(11)70939-3.
The pharmacokinetics and pharmacodynamics of the main antifungal drugs used for invasive fungal infections (amphotéricin B, flucytosine, triazole compounds, echinocandins) have been more or less completely investigated in the paediatric population. This article reviews the pharmacokinetic profiles of these drugs in children, with a focus on the age-related changes. The concentration/efficacy relationships that were evidenced in children are also described.
用于侵袭性真菌感染的主要抗真菌药物（两性霉素B、氟胞嘧啶、三唑类化合物、棘白菌素）的药代动力学和药效学在儿科人群中已或多或少得到了全面研究。本文综述了这些药物在儿童中的药代动力学特征，重点关注与年龄相关的变化。还描述了在儿童中证实的浓度/疗效关系。
