Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin 53705-2281, USA.
Semin Respir Crit Care Med. 2011 Dec;32(6):783-94. doi: 10.1055/s-0031-1295726. Epub 2011 Dec 13.
Pharmacokinetic/pharmacodynamic (PK/PD) studies examine the relationships of drug pharmacokinetic properties, in vitro drug potency, and treatment efficacy. Study results are integral to the design of optimal dosing strategies, prevention of toxicity, development and interpretation of susceptibility break points, and prevention and recognition of drug resistance. These principles are increasingly utilized to optimize therapy for pulmonary fungal pathogens such as ASPERGILLUS species, although they have been underutilized for other difficult-to-treat fungal pathogens. Understanding the design and implementation of PK/PD studies facilitates more effective utilization of the available antifungal agents to improve outcomes for many of these life-threatening infections.
药代动力学/药效动力学（PK/PD）研究探讨了药物药代动力学特性、体外药物效力和治疗效果之间的关系。研究结果是设计最佳给药方案、预防毒性、制定和解释敏感性断点、预防和识别药物耐药性的基础。这些原则越来越多地用于优化治疗肺真菌病原体，如 ASPERGILLUS 物种，尽管它们在其他难以治疗的真菌病原体中未得到充分利用。了解 PK/PD 研究的设计和实施有助于更有效地利用现有抗真菌药物，从而改善许多这些危及生命的感染的治疗效果。
