Department of Radiology, Xuhui Central Hospital of Shanghai and China Academy of Sciences Shanghai Medical Center, 966 Huai Hai Central Road, Shanghai 200031, China.
Eur J Radiol. 2012 Aug;81(8):1712-6. doi: 10.1016/j.ejrad.2011.04.051. Epub 2011 May 19.
To evaluate the feasibility and sensitivity of the 3D-reading of fecal-tagging CT colonography (CTC) with a novel structure-analysis electronic cleansing (SAEC) in detecting colorectal flat lesions in comparison with a cleansed 3D reading with Viatronix V3D Colon system (V3D) and primary uncleansed 2D reading (2D).
Forty CTC cases with flat lesions were retrospectively observed. The Subjects from a multicenter clinical trial underwent cathartic bowel preparation with orally administrated barium-based fecal-tagging. Sixty-nine flat lesions were confirmed using colonoscopy and histopathology as a reference standard. The results from SAEC reading were compared with those of prospective V3D and 2D readings.
Overall detection sensitivity with SAEC was 52% (36/69), which was statistically higher than that of 32% (22/69) and 29% (20/69) with V3D and 2D readings, respectively (p<0.05). The sensitivities in detecting not-on-fold flat lesions were 63% (24/38), 45% (17/38), and 42% (16/38) with SAEC, V3D, and 2D readings, respectively; whereas those of on-fold flat lesions were 39% (12/31), 16% (5/31), and 13% (4/31), respectively. None of the eight flat lesions (2-9mm) at cecum was detected by any of the three reading methods. Excluding the flat lesions at cecum, the sensitivity with SAEC for detecting flat lesion ≥4mm increased to 84% (31/37).
The fecal-tagging CTC with structure-analysis electronic cleansing could yield a high sensitivity for detecting flat lesions ≥4mm. The not-on-fold flat lesions were detected with higher sensitivity than on-fold flat lesions.
评估新型结构分析电子清洁（SAEC）在粪便标记 CT 结肠成像（CTC）三维阅读中检测结直肠扁平病变的可行性和敏感性，并与 Viatronix V3D Colon 系统（V3D）清洁后的三维阅读和原始未清洁的二维阅读（2D）进行比较。
回顾性观察了 40 例具有扁平病变的 CTC 病例。来自多中心临床试验的受试者接受口服钡基粪便标记的通便肠道准备。以结肠镜检查和组织病理学为参考标准，共确认了 69 个扁平病变。将 SAEC 阅读结果与前瞻性 V3D 和 2D 阅读结果进行比较。
SAEC 的总体检测灵敏度为 52%（36/69），与 V3D 和 2D 阅读的 32%（22/69）和 29%（20/69）相比，具有统计学意义（p<0.05）。在检测非褶皱扁平病变时，SAEC、V3D 和 2D 阅读的灵敏度分别为 63%（24/38）、45%（17/38）和 42%（16/38）；而在褶皱扁平病变时，灵敏度分别为 39%（12/31）、16%（5/31）和 13%（4/31）。三种阅读方法均未检测到盲肠处的 8 个（2-9mm）扁平病变。排除盲肠处的扁平病变后，SAEC 检测≥4mm 扁平病变的灵敏度增加至 84%（31/37）。
具有结构分析电子清洁的粪便标记 CTC 可以实现检测≥4mm 扁平病变的高灵敏度。非褶皱扁平病变的检测灵敏度高于褶皱扁平病变。
