Kakugawa Yasuo, Saito Yutaka, Matsuda Takahisa, Nakajima Takeshi, Miyake Mototaka, Iinuma Gen
Division of Screening Technology and Development, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
Int J Mol Sci. 2013 Dec 3;14(12):23629-38. doi: 10.3390/ijms141223629.
To date, few reports focused primarily on detecting colorectal laterally spreading tumors (LSTs) have been published. The aim of this study was to determine the visibility of LSTs on computed tomographic colonography (CTC) compared with that on colonoscopy as a standard. We retrospectively reviewed and matched data on endoscopic and CTC reports in 157 patients (161 LSTs) who received a multidetector CT scan using contrast media immediately after total colonoscopy at the National Cancer Center Hospital in Tokyo, Japan, between December 2005 and August 2010. The results of the total colonoscopy were known at the time of the CTC procedure and reading. Of the 161 LSTs detected on colonoscopy, 138 were observed and matched by CTC (86%). Of the 91 granular type LSTs (LST-Gs), 88 (97%) were observed and matched, while of the 70 non-granular type LSTs (LST-NGs), 50 (71%) were observed and matched by CTC (p<0.0001). CTC enabled observation of 73% (22/30) of 20-29 mm, 83% (35/42) of 30-39 mm, 88% (49/56) of 40-59 mm, and 97% (32/33) of ≥60 mm tumors. The rate of observed LSTs by CTC was 86% (97% of LST-G, 71% of LST-NG) of the LSTs found during total colonoscopy.
迄今为止，主要聚焦于检测大肠侧向发育型肿瘤（LST）的报告发表较少。本研究的目的是确定在计算机断层结肠成像（CTC）上LST的可视性，并与作为标准的结肠镜检查进行比较。我们回顾性分析并匹配了2005年12月至2010年8月期间在日本东京国立癌症中心医院接受全结肠镜检查后立即使用造影剂进行多排CT扫描的157例患者（161个LST）的内镜和CTC报告数据。在进行CTC检查和解读时，全结肠镜检查的结果是已知的。在结肠镜检查中检测出的161个LST中，138个通过CTC观察到并匹配（86%）。在91个颗粒型LST（LST-G）中，88个（97%）被观察到并匹配，而在70个非颗粒型LST（LST-NG）中，50个（71%）通过CTC观察到并匹配（p<0.0001）。CTC能够观察到20-29mm肿瘤的73%（22/30）、30-39mm肿瘤的83%（35/42）、40-59mm肿瘤的88%（49/56）以及≥60mm肿瘤的97%（32/33）。通过CTC观察到的LST率为全结肠镜检查中发现的LST的86%（LST-G的97%，LST-NG的71%）。
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