脂滴的形成：在胰岛素抵抗/2 型糖尿病发展中的可能作用。
The formation of lipid droplets: possible role in the development of insulin resistance/type 2 diabetes.
机构信息
Sahlgrenska Center for Metabolic and Cardiovascular Research, the Department of Molecular and Clinical Medicine, Sahlgenska Academy University of Göteborg, Sweden.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2011 Nov;85(5):215-8. doi: 10.1016/j.plefa.2011.04.019. Epub 2011 May 18.
Neutral lipids are stored in so-called lipid droplets, which are formed as small primordial droplets at microsomal membranes and increase in size by a fusion process. The fusion is catalyzed by the SNARE proteins SNAP23, syntaxin-5 and VAMP4. SNAP23 is involved in the insulin dependent translocation of GLUT4 to the plasma membrane, and has an important role in the development of insulin resistance. Thus fatty acids relocalize SNAP23 from the plasma membrane (and the translocation of GLUT 4) to the interior of the cell giving rise to insulin resistance. Moreover this relocalization is seen in skeletal muscles biopsies from patients with type 2 diabetes compared to matched control. Thus a missorting of SNAP23 is essential for the development of insulin resistance.
中性脂质储存在所谓的脂滴中，这些脂滴最初在微粒体膜上形成小的原始液滴，并通过融合过程增大。融合由 SNARE 蛋白 SNAP23、突触融合蛋白 5 和 VAMP4 催化。SNAP23 参与胰岛素依赖的 GLUT4 向质膜的易位，在胰岛素抵抗的发展中起重要作用。因此，脂肪酸将 SNAP23 从质膜（和 GLUT4 的易位）重新定位到细胞内部，导致胰岛素抵抗。此外，与匹配的对照相比，在 2 型糖尿病患者的骨骼肌活检中可以看到这种再定位。因此，SNAP23 的分选错误对于胰岛素抵抗的发展是必不可少的。
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