长链非编码RNA在脂质稳态中的研究进展与展望
Progress and prospects of long noncoding RNAs in lipid homeostasis.
作者信息
Chen Zheng
机构信息
School of Life Sciences, Northeast Normal University, Changchun, Jilin 130024, China.
出版信息
Mol Metab. 2015 Dec 29;5(3):164-170. doi: 10.1016/j.molmet.2015.12.003. eCollection 2016 Mar.
BACKGROUND
Long noncoding RNAs (lncRNAs) are a novel group of universally present, non-coding RNAs (>200 nt) that are increasingly recognized as key regulators of many physiological and pathological processes.
SCOPE OF REVIEW
Recent publications have shown that lncRNAs influence lipid homeostasis by controlling lipid metabolism in the liver and by regulating adipogenesis. lncRNAs control lipid metabolism-related gene expression by either base-pairing with RNA and DNA or by binding to proteins.
MAJOR CONCLUSIONS
The recent advances and future prospects in understanding the roles of lncRNAs in lipid homeostasis are discussed.
背景
长链非编码RNA（lncRNAs）是一类新发现的广泛存在的非编码RNA（>200个核苷酸），越来越被认为是许多生理和病理过程的关键调节因子。
综述范围
最近的出版物表明，lncRNAs通过控制肝脏中的脂质代谢和调节脂肪生成来影响脂质稳态。lncRNAs通过与RNA和DNA碱基配对或与蛋白质结合来控制脂质代谢相关基因的表达。
主要结论
讨论了在理解lncRNAs在脂质稳态中的作用方面的最新进展和未来前景。
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