Artzi Moran, Sira Liat Ben, Bassan Haim, Gross-Tsur Varda, Berger Irit, Marom Ronella, Leitner Yael, Bental Yoram, Shiff Yakov, Geva Ronny, Weinstein Maya, Bashat Dafna Ben
The Functional Brain Center, The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center (TASMC), Tel Aviv, Israel.
J Child Neurol. 2011 Oct;26(10):1230-6. doi: 10.1177/0883073811402346. Epub 2011 May 18.
Hypoxic-ischemic encephalopathy is an important cause of neuropsychological deficits. Little is known about brain diffusivity in these infants following cooling and its potential in predicting outcome. Diffusion tensor imaging was applied to 3 groups: (1) three infants with hypoxic-ischemic encephalopathy: cooled; (2) three infants with hypoxic-ischemic encephalopathy: noncooled; and (3) four controls. Diffusivity values at the corticospinal tract, thalamus, and putamen were correlated with Apgar scores and early neurodevelopmental outcome. While cooled infants exhibited lower Apgar scores than noncooled infants, their developmental scores at a mean age of 8 months were higher. All groups differed in their diffusivity values with the cooled infants showing better values compared with the noncooled, correlating with early neurodevelopmental outcome. These preliminary results indicate that diffusion tensor imaging performed at an early age in infants with hypoxic-ischemic encephalopathy may forecast clinical outcome and support the neuroprotective effect of hypothermia treatment.
缺氧缺血性脑病是神经心理缺陷的一个重要原因。对于这些婴儿在降温后大脑扩散率及其预测预后的潜力知之甚少。对三组对象进行了扩散张量成像：（1）三名患有缺氧缺血性脑病的婴儿：接受了降温治疗；（2）三名患有缺氧缺血性脑病的婴儿：未接受降温治疗；（3）四名对照组。皮质脊髓束、丘脑和壳核的扩散率值与阿氏评分和早期神经发育结局相关。虽然接受降温治疗的婴儿阿氏评分低于未接受降温治疗的婴儿，但他们在平均8个月龄时的发育评分更高。所有组的扩散率值存在差异，接受降温治疗的婴儿与未接受降温治疗的婴儿相比显示出更好的值，这与早期神经发育结局相关。这些初步结果表明，对患有缺氧缺血性脑病的婴儿在早期进行扩散张量成像可能预测临床结局，并支持低温治疗的神经保护作用。
