MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences, Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.
Science. 2011 May 20;332(6032):917; author reply 917. doi: 10.1126/science.1187374.
Tan et al. (Reports, 25 September 2009, p. 1686) argued that loss of tyrosine residues from proteins in metazoans was driven by positive selection to remove potentially deleterious phosphorylation sites. We challenge this hypothesis, providing evidence that the high guanine-cytosine (GC) content of metazoan genomes was the primary driver in the loss of tyrosine residues.
谭等人（报告，2009 年 9 月 25 日，第 1686 页）认为，后生动物蛋白质中酪氨酸残基的丢失是由正选择驱动的，以去除潜在的有害磷酸化位点。我们对这一假说提出质疑，提供的证据表明，后生动物基因组中的高鸟嘌呤-胞嘧啶（GC）含量是酪氨酸残基丢失的主要驱动因素。
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