Park Young Na, Lee Youn Ju, Choi Jeon Hyeun, Jin Meihua, Yang Ju Hae, Li Ying, Lee Jiean, Li Xian, Kim Keuk-Jun, Son Jong Keun, Chang Hyeun Wook, Kim Jong Yeon, Lee Eunkyung
Research and Development Division, Daegu Gyeongbuk Institute for Oriental Medicine Industry, Gyeongsan, Korea.
Biosci Biotechnol Biochem. 2011;75(5):871-6. doi: 10.1271/bbb.100787. Epub 2011 May 20.
The flowers of Inula japonica (Inulae Flos) have long been used in traditional medicine for treating inflammatory diseases. The effects on OVA-induced asthmatic mice of an Inulae Flos extract (IFE) were evaluated in this study. The anti-asthmatic effects of IFE were determined by observing eosinophil recruitment, airway hyper-responsiveness (AHR), Th2 cytokine and IgE levels, and lung histopathology. The IFE treatment effectively reduced the percentage of eosinophils and Th2 cytokines in the bronchoalveolar lavage fluid (BALF) when compared to the levels in OVA-induced mice. IFE also suppressed AHR induced by aerosolized methacholine in OVA-induced mice. The results of the histopathological studies indicate that inflammatory cell infiltration and mucus hypersecretion were both inhibited by the IFE administration when compared to the effect on OVA-induced mice. The IFE treatment also suppressed the serum IgE levels and decreased Th2 cytokines in the supernatant of cultured splenocytes. These results suggest that IFE may have therapeutic potential against asthma.
旋覆花长期以来一直被用于传统医学治疗炎症性疾病。本研究评估了旋覆花提取物（IFE）对卵清蛋白诱导的哮喘小鼠的影响。通过观察嗜酸性粒细胞募集、气道高反应性（AHR）、Th2细胞因子和IgE水平以及肺组织病理学来确定IFE的抗哮喘作用。与卵清蛋白诱导的小鼠相比，IFE治疗有效地降低了支气管肺泡灌洗液（BALF）中嗜酸性粒细胞和Th2细胞因子的百分比。IFE还抑制了卵清蛋白诱导的小鼠中雾化乙酰甲胆碱诱导的AHR。组织病理学研究结果表明，与对卵清蛋白诱导的小鼠的影响相比，IFE给药可抑制炎症细胞浸润和黏液分泌过多。IFE治疗还抑制了血清IgE水平，并降低了培养脾细胞上清液中的Th2细胞因子。这些结果表明，IFE可能具有抗哮喘的治疗潜力。
