Acar Feridun, Acar Göksemin, Bir Levent Sinan, Gedik Bengi, Oğuzhanoğlu Attila
Department of Neurosurgery, Medical School, Pamukkale University, Denizli, Turkey.
Stereotact Funct Neurosurg. 2011;89(4):214-9. doi: 10.1159/000326617. Epub 2011 May 20.
A 54-year-old male patient presenting probable multiple system atrophy with predominant parkinsonism who underwent bilateral deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is presented. The patient had dominant freezing of gait (FOG), levodopa-resistant bradykinesia, and autonomic disturbances, but with a good cognitive condition.
The patient underwent bilateral DBS of the PPN, which ended with modest benefits.
Although he had a short postoperative follow-up (6 months), his neurological status remained stable and PPN DBS provided modest improvements in the gait disorder and freezing episodes. This unusual case suggests that the mesencephalic pedunculopontine region may have a role in locomotor symptoms and the potential to provide a limited improvement in FOG.
本文介绍了一名54岁男性患者，其表现为可能的以帕金森综合征为主的多系统萎缩，并接受了双侧脚桥核（PPN）深部脑刺激（DBS）治疗。该患者主要存在步态冻结（FOG）、左旋多巴抵抗性运动迟缓及自主神经功能障碍，但认知状况良好。
该患者接受了双侧PPN-DBS治疗，术后效果一般。
尽管术后随访时间较短（6个月），但其神经状态保持稳定，PPN-DBS在步态障碍和冻结发作方面有一定改善。该罕见病例提示中脑脚桥核区域可能在运动症状中起作用，并且有可能在一定程度上改善FOG。
