一名原发性进行性冻结步态障碍患者的脚桥核深部脑刺激术
Pedunculopontine nucleus deep brain stimulation in a patient with primary progressive freezing gait disorder.
作者信息
Ostrem Jill L, Christine Chadwick W, Glass Graham A, Schrock Lauren E, Starr Philip A
机构信息
Department of Neurology, University of California San Francisco, Center for the Surgical Treatment of Movement Disorders, San Francisco, CA 94143, USA.
出版信息
Stereotact Funct Neurosurg. 2010;88(1):51-5. doi: 10.1159/000268742. Epub 2009 Dec 24.
BACKGROUND
Pedunculopontine nucleus (PPN) deep brain stimulation (DBS) has recently been suggested for treatment of medication-unresponsive gait and axial symptoms in Parkinson's disease. Patients with the rare primary progressive freezing gait disorder (PPFG) have similar disabling symptoms and few therapeutic options. We report here on our experience with PPN DBS in treating a 76-year-old man with medication-refractory PPFG.
METHODS
The patient was treated with staged PPN DBS and underwent careful pre- and postoperative clinical evaluations up to 12 months after surgery.
RESULTS
PPN DBS resulted in only mild improvement in symptoms after 12 months of stimulation.
CONCLUSION
In this single case of a patient with PPFG, PPN DBS served only a limited role in treating his symptoms and adds to the very limited published literature describing patients treated with DBS at this brain target.
背景
最近有人提出，对帕金森病中药物治疗无效的步态和轴性症状可采用脚桥核（PPN）深部脑刺激（DBS）进行治疗。患有罕见的原发性进行性冻结步态障碍（PPFG）的患者有类似的致残症状且治疗选择有限。我们在此报告我们对一名76岁药物难治性PPFG男性患者进行PPN DBS治疗的经验。
方法
该患者接受了分期PPN DBS治疗，并在术后长达12个月的时间里接受了仔细的术前和术后临床评估。
结果
刺激12个月后，PPN DBS仅使症状有轻微改善。
结论
在这例PPFG患者中，PPN DBS在治疗其症状方面作用有限，这也为描述在此脑靶点接受DBS治疗患者的非常有限的已发表文献增添了内容。
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